Regulation of mammalian heart development by transcription factors FHL2, GATA-4 & FOG-2

转录因子 FHL2、GATA-4 对哺乳动物心脏发育的调节

• 批准号: DP0558687
• 负责人: Prof Beng Chong
• 金额: $ 15.96万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0558687
• 关键词: Regulation; mammalian; heart; development; transcription

FHL2 is involved in many biological processes including intracellular signaling and gene transcription. GATA and FOG proteins are critical for the development of diverse tissues, including the heart. Knowledge gained in this project will advance our understanding of many cellular processes, including heart development, and will contribute to our knowledge in Biology, Zoology and Veterinary Science. More specifically, it will contribute to Stem Cell research, a 'hot' area in the biotechnology industry, particularly towards building a strong base of expertise, skills and technological capability in this new field, and may even lead to the development of a commercial product e.g. a heart muscle cell-coated biomaterial to aid failing heart.

FHL2参与许多生物学过程，包括细胞内信号传导和基因转录。加塔和FOG蛋白对包括心脏在内的各种组织的发育至关重要。在这个项目中获得的知识将促进我们对许多细胞过程的理解，包括心脏发育，并将有助于我们在生物学，动物学和兽医学方面的知识。更具体地说，它将有助于干细胞研究，这是生物技术行业的一个“热门”领域，特别是在这个新领域建立强大的专业知识，技能和技术能力基础，甚至可能导致商业产品的开发，例如心肌细胞涂层生物材料，以帮助心脏衰竭。