CORE--CLINICAL FACILITY

临床核心将提供一种通用机制，通过该机制对研究受试者进行表征，并收集受试者和家族信息（包括生物样本）。在临床核心集中和协调这些活动将为计划的项目创造效率，并应刺激STAART自闭症研究人员之间的额外合作，以及在有限的程度上，研究人员不受STAART资助。将生成一个共享核心数据集，包括STAART研究中所有潜在参与者的基本描述性信息。此外，该核心还将协助具体项目的数据管理， 统计分析。虽然临床核心将有两个地点（肯尼迪克里格研究所和儿童国家医疗中心），但临床活动的运作相互补充，在概念上是相似的。这一核心的具体目标包括： 1.确定和招募STAART研究参与者; 2.确定参与者的资格; 3.对受试者进行诊断评估; 4.进行自闭症诊断评估的评分者间可靠性试验; 5.监控测试管理的准确性; 6.进行成果数据收集; 7.便利生物样本的收集和分发; 8.提供数据存储和数据管理支持。

The Clinical Core will provide a common mechanism through which study subjects are characterized, and subject and family information (including biologic samples) is collected. Centralizing and coordinating these activities in the Clinical Core will create efficiencies for the planned projects and should stimulate additional collaborations between STAART autism researchers as well as, to a limited degree, researchers not funded by STAART. A shared core dataset including basic descriptive information on all potential participants in the STAART studies will be generated. In addition, the core will assist in project-specific data management and statistical analyses. Although there will be two sites for the clinical core (Kennedy Krieger Institute and Children's National Medical Center), the operations of the clinical activities complement each other and are conceptually similar. Specific objectives of this core include: 1. identifying and recruiting STAART research participants; 2. determining eligibility of participants; 3. conducting diagnostic assessments of subjects; 4. conducting inter-rater reliability trials for autism diagnostic assessments; 5. monitoring the fidelity of test administration; 6. conducting outcome data collection; 7. facilitating the collection and distribution of biological samples; 8. providing data storage and data management support.