CORE--CLINICAL FACILITY

临床核心将提供一个共同的机制，通过该机制对研究对象进行特征描述，并收集受试者和家庭信息（包括生物样本）。在临床中心集中和协调这些活动将为计划中的项目创造效率，并应刺激STAART自闭症研究人员之间的额外合作，以及在一定程度上，非STAART资助的研究人员。将生成一个共享的核心数据集，其中包括STAART研究所有潜在参与者的基本描述性信息。此外，该核心将协助具体项目的数据管理和

The Clinical Core will provide a common mechanism through which study subjects are characterized, and subject and family information (including biologic samples) is collected. Centralizing and coordinating these activities in the Clinical Core will create efficiencies for the planned projects and should stimulate additional collaborations between STAART autism researchers as well as, to a limited degree, researchers not funded by STAART. A shared core dataset including basic descriptive information on all potential participants in the STAART studies will be generated. In addition, the core will assist in project-specific data management and statistical analyses. Although there will be two sites for the clinical core (Kennedy Krieger Institute and Children's National Medical Center), the operations of the clinical activities complement each other and are conceptually similar. Specific objectives of this core include: 1. identifying and recruiting STAART research participants; 2. determining eligibility of participants; 3. conducting diagnostic assessments of subjects; 4. conducting inter-rater reliability trials for autism diagnostic assessments; 5. monitoring the fidelity of test administration; 6. conducting outcome data collection; 7. facilitating the collection and distribution of biological samples; 8. providing data storage and data management support.