CORE--CLINICAL FACILITY

核心——临床设施

• 批准号: 7551728
• 负责人: ELAINE TIERNEY
• 金额: $ 23.46万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-03 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7551728
• 关键词: Achievement; Adaptive Behaviors; Advocacy; Area; Autistic Disorder; Baltimore; Behavior; Behavior assessment; Biological; Child; Childhood; Clinic; Clinical; Clinical Research; Clinical assessments; Collaborations; Collection; Communication; Complement; Data; Data Collection; Data Set; Data Storage and Retrieval; Development; Diagnosis; Diagnostic; Disabled Children; Disease; Eligibility Determination; Epidemiologic Studies; Family; Funding; Infant; Information Storage; Institutes; Institution; Internet; Interview; Measures; Medical center; Medicine; Mental Retardation; Monitor; Motor; Neurology; Neuropsychology; Newsletter; Numbers; Operative Surgical Procedures; Outcome; Parents; Participant; Patients; Productivity; Protocols documentation; Psychiatrist; Psychiatry; Psychology; Psychopharmacology; Quality Control; Recruitment Activity; Registries; Religion and Spirituality; Research; Research Personnel; Resources; Sampling; Schedule; Schools; Services; Site; Societies; Special Education; Study Subject; System; Testing; Therapeutic; Training; Washington; clinical research site; data management; day; human subject; neurobehavioral; neuropsychological; pediatrician; programs; psychologic; success

The Clinical Core will provide a common mechanism through which study subjects are characterized, and subject and family information (including biologic samples) is collected. Centralizing and coordinating these activities in the Clinical Core will create efficiencies for the planned projects and should stimulate additional collaborations between STAART autism researchers as well as, to a limited degree, researchers not funded by STAART. A shared core dataset including basic descriptive information on all potential participants in the STAART studies will be generated. In addition, the core will assist in project-specific data management and statistical analyses. Although there will be two sites for the clinical core (Kennedy Krieger Institute and Children's National Medical Center), the operations of the clinical activities complement each other and are conceptually similar. Specific objectives of this core include: 1. identifying and recruiting STAART research participants; 2. determining eligibility of participants; 3. conducting diagnostic assessments of subjects; 4. conducting inter-rater reliability trials for autism diagnostic assessments; 5. monitoring the fidelity of test administration; 6. conducting outcome data collection; 7. facilitating the collection and distribution of biological samples; 8. providing data storage and data management support.

临床核心将提供一个共同的机制，通过它来确定研究对象的特征，并收集对象和家庭信息(包括生物样本)。在临床核心中心集中和协调这些活动将为计划的项目创造效率，并应促进STAART自闭症研究人员以及在有限程度上不受STAART资助的研究人员之间的更多合作。将生成一个共享的核心数据集，其中包括STAART研究中所有潜在参与者的基本描述性信息。此外，核心将协助具体项目的数据管理和 统计分析。虽然临床核心将有两个地点(肯尼迪·克里格研究所和儿童国家医学中心)，但临床活动的运作是相辅相成的，在概念上是相似的。这一核心的具体目标包括： 1.确定和招募STAART研究参与者； 2.确定参与者的资格； 3.对受试者进行诊断评估； 4.进行自闭症诊断评估的评分员间可靠性试验； 5.监督考试管理的保真度； 6.进行结果数据收集； 7.便利生物样本的收集和分发； 8.提供数据存储和数据管理支持。