Bioactive Biodegradable Nano-Composite (BBNC) Materials for Regnerative Medicine

骨科研究单位将评估人体细胞对可生物降解纳米复合材料的反应。这将确定这些材料是否可以支持导致骨形成的细胞功能，以及是否存在材料的活性细胞去除。这项工作还旨在了解对这些材料的生物反应背后的机制。将通过植入和测量其支持骨形成的能力来评估选定的纳米复合材料。将测量其与骨相互作用的机械强度及其随后的降解速率。这些结果将允许评估这些材料对特定功能的适用性，例如作为骨折固定的棒和板或作为将受损骨固定在一起的螺钉，并指出优于当前材料的优点。

The Orthopaedic Research Unit will evaluate the response of human cells to the biodegradable nano-composite materials. This will determine whether these materials can support cellular functions leading to bone formation and whether there is active cellular removal of the material. This work also aims to understand the mechanisms behind the biological response to these materials. Selected nano-composites will be assessed by implantation and measurement of their ability to support bone formation. The mechanical strength of their interaction with bone and their subsequent rate of degradation will be measured. The results will allow the suitability of these materials for particular functions, for example as rods and plates for fracture fixation or as screws for holding damaged bone together, to be assessed and indicate advantages over current materials.