Plasma-based surface modifications and nano-structured multifunctional coatings for the next generation of biodegradable Mg-based bone-contact implants

如今，牙科植入物的使用非常普遍，2016年全球牙科植入物市场规模为37.7亿美元。植入物的积极结果与几个因素有关，例如，当不充分时需要增强的固定骨的质量。有几种临床程序可用。例如，通过膜的引导骨再生（GBR）是公认的对患者具有低侵入性的临床实践。然而，两种市售生物材料（多孔钛或胶原基膜）存在一些缺点。当愈合完成时，需要去除多孔钛，而胶原基膜表现出不可控制的降解速率。启动新生物材料查询。可吸附的金属生物材料，主要是镁基（由于其固有的骨诱导性），是特别感兴趣的。一方面，它们与Ti的机械性能相匹配。此外，另一方面，它们与基于胶原蛋白的溶液的生物功能相匹配。具有目标化学配方的镁基材料具有与骨科器械兼容的机械、电化学和生物学特性。此外，GBR所需的受控降解速率、机械阻力和细胞相容性可以通过改善生物材料的表面性质来实现。纳米结构涂层可以为材料提供改善的抗菌行为，增加射线不透性，增强骨传导性，甚至促进细胞粘附。这些特征可以通过镁合金基材的多步骤表面改性工艺来实现，该工艺包括电化学预处理、基于等离子体的沉积和后处理。该项目的目的是设计，优化和验证这个多步骤的过程。通过密切合作，拉瓦尔大学，Plasmionique和生物技术公司将探索具有先进功能的新型生物降解涂层的可行性。该项目的多功能性将使这些新的可降解生物材料适用于广泛的骨接触应用，包括牙科和骨科。

The use of dental implant is nowadays quite widespread, with a global dental implants market size valued at USD 3.77 billion in 2016. The positive outcome of the implant is related to several factors, such as, for example, the quality of the fixation bone that needs to be augmented when insufficient. Several clinical procedures are available. For example, guided bone regeneration (GBR) by membranes is a clinical practice recognised for being low invasive for the patient. Nevertheless, the two commercially available class of biomaterials (porous Ti or collagen-based membranes) present some drawbacks. Porous Ti needs to be removed when healing is completed, while collagen-based membranes exhibit an uncontrollable degradation rate. The query for new biomaterials is launched. Adsorbable metallic biomaterial, mainly Mg-based (for their intrinsic osteo-inductivity), are of particular interest. In one hand, they match the mechanical properties of Ti. In addition, in the other hand, they match the bio-functionality of collagen-based solutions. Magnesium-based materials, with targeted chemical formulations, lead to mechanical, electrochemical and biological properties compatible with orthopedic devices. Furthermore, the controlled degradation rate, the mechanical resistance and the cytocompatibility that is required from GBR, can be achieved by improving the surface properties of the biomaterial. A nanostructured coating can provide the material with an improved antibacterial behaviour, increase the radiopacity, enhance osteoconductivity, and even promote cell adhesion. These features can be targeted by a multi-step surface modification process of the Mg-alloy substrate, which include electrochemical pre-treatment, plasma-based deposition and a post-treatment. The aim of this project is to design, optimise and validate this multi-step process leading. By closing working together, Laval University, Plasmionique and Biotrics will explore the feasibility of a new class of biodegradable coatings with advanced functionalities. The versatility targeted in this project will make these new degradable biomaterials for a wide range of bone-contact applications, including dental and orthopedic.