Disposable Respiratory Flow Measurement Device

一次性呼吸流量测量装置

• 批准号: 7539571
• 负责人: BENJAMIN R LANE
• 金额: $ 11.97万
• 依托单位: KEY TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2009-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7539571
• 关键词: Accelerated Phase; Accounting; Adult; Affect; Air; Ambulatory Monitoring; Anesthesia procedures; Appendix; Applications Grants; Area; Baltimore; Benchmarking; Breathing; Cannulas; Child; Childhood; Chronic Obstructive Airway Disease; Clinic; Clinical; Clinical Medicine; Coin; Consult; Critiques; Data; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Procedure; Discipline; Electronics; Environment; Environmental air flow; Event; Exhalation; Face; Failure; Feedback; Frequencies; Funding; Future; Goals; Gold; Grant; Home environment; Hospitals; Hour; Human; Humidity; Hypercapnic respiratory failure; Industry; Knowledge; Laboratories; Longitudinal Studies; Manufacturer Name; Marketing; Masks; Measurement; Measures; Mechanics; Medical; Medicine; Methods; Mirage; Modification; Monitor; Morphologic artifacts; Motion; Mouth Breathing; Nose; Numbers; OSA; Oral; Patient Care; Patient Monitoring; Patients; Pattern; Performance; Phase; Physiological; Plastics; Play; Polysomnography; Population; Positioning Attribute; Procedures; Production; Public Health; Published Comment; Pulmonology; Purpose; Range; Recommendation; Relative (related person); Reproducibility; Research; Research Personnel; Resistance; Respiration; Science; Signal Transduction; Sleep; Sleep Disorders; Standards of Weights and Measures; System; Techniques; Technology; Telephone; Temperature; Test Result; Testing; Tidal Volume; Time; Tooth structure; Translating; Tube; Validation; Variant; Wireless Technology; Work; base; commercialization; computerized data processing; concept; cost; day; design; face mask; improved; innovation; meter; milliliter; performance tests; pressure; prototype; research and development; respiratory; response; sensor; size; success; tool; transmission process; usability; validation studies

DESCRIPTION (provided by applicant): The overall goal of this project is to develop, formally benchmark and validate a new flow sensor that will accurately quantify varying degrees of ventilation in pediatric and adult patient populations. The flow sensor is a simple, non-contact, disposable part that provides quantitative measurement of respiratory activity, even in the low-flow range. Current technologies lack the ability to accurately measure tidal volume but rather provide a semi-quantitative measure of respiratory patterns. A pneumotachograph (which can provide quantitative data) is too burdensome on patient comfort and breathing effort to obtain long term respiration measurements. Self-funded preliminary prototypes were developed prior to this grant submission and tested at the Johns Hopkins Sleep Disorders Center in Baltimore. The prototypes performed comparable to the gold standard (pneumotachograph). This project will finish development of the design, formally benchmark the flow sensor with the pneumotachograph, as well as examine the stability and accuracy of the design. Following this, the design will undergo planned improvements related to patient comfort and compliance. The project will conclude with formal clinical validation studies at overnight sleep clinics across a spectrum of patients to compare and validate the new flow sensor to current technology. Final design modifications will focus on optimization of a "plug-and-play" interface thereby simplifying integration with existing polysomnographic recording units and improving technician ease of use and patient comfort. The data and prototypes generated by this application will ultimately translate into improved care of patients that are susceptible to ventilatory failure and eventually as an ambulatory diagnostic system for patients in the home setting. This flow sensor will have an immediate impact on patient monitoring in sleep laboratories and will further influence diagnostic procedures in pulmonary medicine, anesthesia and other medical disciplines. PUBLIC HEALTH RELEVANCE: The proposed project will develop, formally benchmark and validate a new flow sensor that will allow the medical industry to accurately quantify ventilation. This flow sensor will measure a broad range of respiratory events, including subtle changes of breathing, in both pediatric and adult populations. Initially the flow sensor will be used as a diagnostic tool in the sleep lab environment, while future applications will include the flow sensor as a critical component of patient care in the hospital in-patient and ER as well as an ambulatory diagnostic tool for patients in the home setting.

描述（由申请人提供）：该项目的总体目标是开发，正式基准并验证一个新的流动传感器，该传感器将准确地量化儿科和成人患者人群中不同程度的通风。流动传感器是一个简单的，非接触的一次性部分，即使在低流量范围内，也可以对呼吸活性进行定量测量。当前的技术缺乏准确测量潮汐量的能力，而是提供半定量措施的呼吸模式。在患者的舒适性和呼吸努力上，无法获得长期呼吸测量，气动扫描（可以提供定量数据）太繁重了。在此赠款提交之前开发了自资助的初步原型，并在巴尔的摩的约翰·霍普金斯睡眠障碍中心进行了测试。这些原型的执行功能与金标准（Pneumotachograph）相当。该项目将完成设计的开发，并用气动扫描仪正式对流动传感器进行基准测试，并检查设计的稳定性和准确性。在此之后，该设计将经过与患者舒适性和合规性有关的计划改进。该项目将在一系列患者的过夜睡眠诊所进行正式的临床验证研究，以比较和验证新的流动传感器与当前技术。最终的设计修改将着重于优化“插件”界面，从而简化了与现有的多聚会记录单元的集成，并提高了技术人员的易用性和患者舒适性。该应用程序产生的数据和原型最终将转化为易受通风衰竭的患者的护理，并最终作为家庭环境中患者的门诊诊断系统。该流动传感器将对睡眠实验室中的患者监测产生直接影响，并将进一步影响肺医学，麻醉和其他医疗学科的诊断程序。公共卫生相关性：拟议的项目将开发，正式基准并验证一种新的流动传感器，该传感器将使医疗行业能够准确量化通风。该流量传感器将测量小儿和成人种群中的广泛呼吸事件，包括呼吸的细微变化。最初，该流量传感器将用作睡眠实验室环境中的诊断工具，而将来的应用将包括流动传感器作为住院和ER的患者护理的关键组成部分，以及用于家庭环境中患者的门诊诊断工具。