Disposable Respiratory Flow Measurement Device

一次性呼吸流量测量装置

基本信息

批准号：
7760004
负责人：
BENJAMIN R LANE
金额：
$ 65.51万
依托单位：
KEY TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-01 至 2011-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7760004
关键词：
Accelerated Phase Accounting Adult Affect Air Ambulatory Monitoring Applications Grants Area Benchmarking Breathing Cannulas Child Childhood Chronic Obstructive Airway Disease Clinical Clinical Medicine Coin Consult Critiques Data Detection Development Devices Diagnosis Diagnostic Electronics Environment Environmental air flow Event Exhalation Face Feedback Frequencies Funding Future Grant Home environment Hospitals Hour Human Humidity Hypercapnic respiratory failure Industry Knowledge Laboratories Longitudinal Studies Manufacturer Name Marketing Masks Measurement Measures Mechanics Medical Medicine Methods Mirage Monitor Morphologic artifacts Motion Mouth Breathing Nose Oral Patient Care Patients Performance Phase Physiological Plastics Play Polysomnography Population Positioning Attribute Procedures Production Published Comment Recommendation Relative (related person)Reproducibility Research Research Personnel Resistance Respiration Science Signal Transduction Sleep System Techniques Technology Telephone Temperature Test Result Testing Tidal Volume Time Tooth structure Tube Validation Variant Wireless Technology Work base commercialization computerized data processing cost data exchange design face mask improved innovation meter milliliter patient population performance tests pressure prototype public health relevance research and development respiratory response sensor success tool usability validation studies verification and validation

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this project is to develop, formally benchmark and validate a new flow sensor that will accurately quantify varying degrees of ventilation in pediatric and adult patient populations. The flow sensor is a simple, non-contact, disposable part that provides quantitative measurement of respiratory activity, even in the low-flow range. Current technologies lack the ability to accurately measure tidal volume but rather provide a semi-quantitative measure of respiratory patterns. A pneumotachograph (which can provide quantitative data) is too burdensome on patient comfort and breathing effort to obtain long term respiration measurements. Self-funded preliminary prototypes were developed prior to this grant submission and tested at the Johns Hopkins Sleep Disorders Center in Baltimore. The prototypes performed comparable to the gold standard (pneumotachograph). This project will finish development of the design, formally benchmark the flow sensor with the pneumotachograph, as well as examine the stability and accuracy of the design. Following this, the design will undergo planned improvements related to patient comfort and compliance. The project will conclude with formal clinical validation studies at overnight sleep clinics across a spectrum of patients to compare and validate the new flow sensor to current technology. Final design modifications will focus on optimization of a "plug-and-play" interface thereby simplifying integration with existing polysomnographic recording units and improving technician ease of use and patient comfort. The data and prototypes generated by this application will ultimately translate into improved care of patients that are susceptible to ventilatory failure and eventually as an ambulatory diagnostic system for patients in the home setting. This flow sensor will have an immediate impact on patient monitoring in sleep laboratories and will further influence diagnostic procedures in pulmonary medicine, anesthesia and other medical disciplines.

描述（由申请人提供）：该项目的总体目标是开发，正式基准并验证一个新的流动传感器，该传感器将准确地量化儿科和成人患者人群中不同程度的通风。流动传感器是一个简单的，非接触的一次性部分，即使在低流量范围内，也可以对呼吸活性进行定量测量。当前的技术缺乏准确测量潮汐量的能力，而是提供半定量措施的呼吸模式。在患者的舒适性和呼吸努力上，无法获得长期呼吸测量，气动扫描（可以提供定量数据）太繁重了。在此赠款提交之前开发了自资助的初步原型，并在巴尔的摩的约翰·霍普金斯睡眠障碍中心进行了测试。这些原型的执行功能与金标准（Pneumotachograph）相当。该项目将完成设计的开发，并用气动扫描仪正式对流动传感器进行基准测试，并检查设计的稳定性和准确性。在此之后，该设计将经过与患者舒适性和合规性有关的计划改进。该项目将在一系列患者的过夜睡眠诊所进行正式的临床验证研究，以比较和验证新的流动传感器与当前技术。最终的设计修改将着重于优化“插件”界面，从而简化了与现有的多聚会记录单元的集成，并提高了技术人员的易用性和患者舒适性。该应用程序产生的数据和原型最终将转化为易受通风衰竭的患者的护理，并最终作为家庭环境中患者的门诊诊断系统。该流动传感器将对睡眠实验室中的患者监测产生直接影响，并将进一步影响肺医学，麻醉和其他医疗学科的诊断程序。