Implantable glucose sensor with prolonged accuracy

具有长期准确度的植入式葡萄糖传感器

• 批准号: 7714649
• 负责人: Melissa M Reynolds
• 金额: $ 41.82万
• 依托单位: ACCORD BIOMATERIALS, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714649
• 关键词: Address; Adhesions; Amplifiers; Animal Testing; Area; Benchmarking; Blood; Blood Circulation; Blood Glucose; Blood Platelets; Canis familiaris; Caring; Catheters; Characteristics; Clinical; Complex; Critical Illness; Custom; Development; Devices; Diffusion; Drug Formulations; Ensure; Glucose; Goals; Grant; Health; Health Care Costs; Health Professional; Hemostatic Agents; Housing; Implant; In Vitro; Insulin; Intensive Care Units; Lead; Life; Marketing; Measurement; Measures; Mechanics; Membrane; Methods; Modeling; Monitor; Nitric Oxide; Patient Care; Patients; Performance; Phase; Physiological; Polymers; Reading; Recovery; Research; Resistance; Risk; Site; Standards of Weights and Measures; Sterilization for infection control; System; Technology; Testing; Vertebral column; base; biocompatible polymer; biomaterial compatibility; cytotoxicity; cytotoxicity test; day; design; glucose sensor; improved; in vivo; point of care; prevent; prototype; research and development; sensor; subcutaneous

DESCRIPTION (provided by applicant): The goal of this study is to fabricate an intravascular glucose sensor that functions accurately for 7 days in vivo. We will utilize a glucose membrane design devised in Phase I to develop a custom outer membrane that has covalently attached bioactive sites to resist biofouling, allows for suitable glucose diffusion, and prevents leaching of potentially toxic by-products. This membrane will be applied to needle-type, amperometric glucose sensor. The versatility of the sensor design will allow easy incorporation into a patient's bloodstream through a central access catheter. The catheter will be designed for 7 day use in the intensive care unit, and will be complete with a hemostatic connector for attaching to an access line, and the electrical connections to an amplifier/display unit. The final prototype will be evaluated for cytotoxicity, hemocompatibilty, and accuracy both using in vitro and in vivo methods. Continuous monitoring of blood glucose levels has been an elusive goal, but would greatly improve the care for critically ill patients in managing insulin therapy. PUBLIC HEALTH RELEVANCE: The goal in this grant is to make an intravascular glucose sensor that measures blood glucose levels continuously for 7 days. By maintaining sensor function, this technology will provide health care professionals with immediate changes in patient health and decrease complications. Currently sudden changes in glucose levels are not detected leading to increased health care costs and increased risks to patients.

描述（由申请人提供）：本研究的目的是制造一种血管内葡萄糖传感器，该传感器在体内准确运行7天。我们将利用第一阶段设计的葡萄糖膜设计开发一种定制的外膜，该外膜具有共价连接的生物活性位点以抵抗生物污染，允许适当的葡萄糖扩散，并防止潜在有毒副产物的浸出。该膜将应用于针型电流型葡萄糖传感器。传感器设计的多功能性将允许通过中心接入导管容易地并入患者的血流中。导管设计为可在重症监护室中使用7天，并配有止血连接器，用于连接到接入管路，以及与放大器/显示单元的电气连接。将使用体外和体内方法评价最终原型的细胞毒性、血液相容性和准确性。持续监测血糖水平一直是一个难以实现的目标，但将大大改善危重患者在管理胰岛素治疗方面的护理。公共卫生关系：这项资助的目标是制造一种血管内葡萄糖传感器，可以连续7天测量血糖水平。通过保持传感器功能，该技术将为医疗保健专业人员提供患者健康的即时变化并减少并发症。目前，葡萄糖水平的突然变化未被检测到，导致医疗保健成本增加和患者风险增加。