Catheters Designed for Decreased Clotting and Infection

专为减少凝血和感染而设计的导管

• 批准号: 7218776
• 负责人: Melissa M Reynolds
• 金额: $ 11.66万
• 依托单位: MC3, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-26 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7218776
• 关键词: Active Sites; Adhesions; Benchmarking; Binding; Biochemistry; Biocompatible; Biocompatible Materials; Biological Assay; Biomimetic Materials; Blood; Blood Platelets; Buffers; Caring; Catheters; Cessation of life; Chemistry; Coagulation Process; Complex; Condition; Devices; Endothelial Cells; Evaluation; Filler; Generations; Goals; Grant; Growth; Health Care Costs; Healthcare; Heparin; Heparin Binding; Immobilization; In Vitro; Infection; Inpatients; Intensive Care Units; Life; Liquid substance; Longevity; Marketing; Mechanics; Medical; Membrane; Methods; Microbe; Monitor; Morbidity - disease rate; Nature; Nitric Oxide; Outpatients; Patients; Pharmaceutical Preparations; Phase; Platelet Activation; Poisoning; Polymers; Property; Protective Agents; Rate; Research; Resistance; Risk; Selenium; Solvents; Surface; Swelling; Technology; Time; Venous; antimicrobial; base; biomaterial compatibility; day; design; implantable device; improved; in vivo; innovative technologies; manufacturing process; microbial; next generation; novel; novel strategies; nutrition; patient safety; prevent

DESCRIPTION (provided by applicant): The goal is this study is to fabricate an intravascular dual-functioning catheter that prevents both clotting and infection. This will be accomplished by combining novel selenium (Se) chemistries with surface bound heparin. The goals of this phase I application are targeted at developing the manufacturing processes for incorporating the Se-complexes into the polymer of the catheter, immobilizing heparin on the surface of the catheter, and evaluating the in vitro antimicrobial and antiplatelet function of the device. Specifically, the aims are: 1. Design a biocompatible central venous catheter with antithrombotic and antimicrobial properties using two fabrication methods. 2. Compare the fabrication methods to maximize functionality 3. Conduct preliminary antimicrobial and antiplatelet assays with the coated catheters. This approach is a significant advance in improving the biocompatibility design features of catheters, as it mimics a Se-based, catalytic chemistry present in endothelial cell biochemistry. By decreasing clotting and infection, this technology will simultaneously increase catheter longevity and decrease patient morbidity. Currently infected or clotted catheters have to be removed and replaced leading to increased health care costs and increased risks to patients. The ubiquitous nature of these devices in modern health care suggests a vast potential market for this innovative technology. The goal in this grant is to make an intravascular dual-functioning catheter that prevents both clotting and infection. By decreasing clotting and infection, this technology will simultaneously increase the life- time of the catheter and decrease patient death. Currently infected or clotted catheters have to be removed and replaced leading to increased health care costs and increased risks to patients.

描述（由申请人提供）：本研究的目标是制造一种血管内双重功能的导管，以防止凝血和感染。这将通过将新的硒（Se）化学物质与表面结合的肝素结合来实现。该I期申请的目标是开发将硒络合物结合到导管聚合物中的制造工艺，将肝素固定在导管表面，并评估该装置的体外抗菌和抗血小板功能。具体来说，目标是：1。采用两种制造方法设计一种具有抗血栓和抗菌性能的生物相容性中心静脉导管。2. 比较制造方法，以最大限度地发挥功能3。用包被导管进行初步抗菌和抗血小板试验。这种方法在改善导管的生物相容性设计特征方面取得了重大进展，因为它模拟了内皮细胞生物化学中存在的se基催化化学。通过减少凝血和感染，该技术将同时延长导管的使用寿命并降低患者的发病率。目前感染或凝血的导管必须移除并更换，导致医疗费用增加，患者风险增加。这些设备在现代医疗保健中无处不在，这表明这种创新技术具有巨大的潜在市场。这项研究的目标是制造一种血管内双重功能的导管，既能防止凝血又能防止感染。通过减少凝血和感染，该技术将同时延长导管的使用寿命并减少患者死亡。目前感染或凝血的导管必须移除并更换，导致医疗费用增加，患者风险增加。