Animal Core

动物核心的总体目标是为项目负责人提供利用动物 致癌模型在执行其研究项目，并保持基因工程 动物用于研究癌症发病机制。动物核心将 作为一个资源进行使用的所有动物操纵所需的程序。动物 核心将最大限度地减少在计划研究项目中使用动物模型的成本， 设备、专业知识和动物资源。这将确保最低限度的有效利用动物研究 这将降低成本，并减少可能影响项目间数据分析的变量。的总体目标 具体目标：1。确保有效规划、采购和利用实验性 动物，包括转基因和基因改变的小鼠;保持所有动物的库存;和繁殖 动物为个别项目。我们将维持项目研究所需的动物， 与项目负责人合作，确定并生成拟议研究所需的动物。具体 目标二。为致癌模型提供必要的设施和专业知识，以支持 研究项目。核心将提供癌症动物模型的资源和专业知识， 炎症这将包括结肠、舌（头和颈）、乳腺、前列腺和肺癌发生模型 使用化学致癌物或基因工程小鼠癌症模型以及炎症模型。 具体目标3。提供啮齿动物病理学方面的专业知识，并掌握最新的癌症知识 病理生物学核心主任在病理学领域拥有广泛的专业知识， 基础设施演进核心将组织动物数据库，包括动物健康和最终病理 尸检时评价。该数据库将用于输入由 项目，以允许复杂的、基于互相关的数据分析。这些努力将有助于开展 研究本提案，并将提供专业知识，以支持项目负责人。随着合并 在鞘脂的致癌模型和基因工程小鼠模型中，这一核心已经被 发展成为一个独特的、使能的核心，对计划项目的成功至关重要。

The overall objective of the Animal Core is to provide the Project Leaders with the ability to utilize animal carcinogenesis models in the execution of their research projects and to maintain genetically engineered animals for the investigation of the mechanisms involved in the pathogenesis of cancer. The Animal Core will serve as a resource for conducting the use of all animal manipulations needed in the program. The Animal Core will minimize the cost of utilizing animal models in the Program research projects by consolidating the equipment, expertise, and animal resources. This will ensure an efficient use of animal research at minimal cost and will reduce variables that could compromise data analysis among projects. The overall aims of the proposal are: Specific Aim 1. Ensure the efficient planning, purchase, and utilization of experimental animals, including transgenic and genetically altered mice; maintain stocks of all animals; and breed animals for the individual Projects. We will maintain the animals needed for the Project's research and will work with the Project Leaders to identify and generate animals needed for the proposed studies. Specific Aim 2. Provide the necessary facilities and expertise for carcinogenesis models to support the Research Projects. The Core will provide resources and expertise in animal models of cancer and inflammation. This will include colon, tongue (head & neck), breast, prostate, and lung carcinogenesis models using chemical carcinogens or genetically engineered mouse cancer models as well as inflammation models. Specific Aim 3. Provide expertise in rodent pathology with up-to-date proficiency in cancer pathobiology. The Core director has extensive expertise in the area of pathology to provide the necessary infrastructure. The Core will organize the animal database including animal health and final pathological evaluations at necropsy. This database will be used to input all animal-specific results obtained by the Projects, to allow complex, cross-correlation-based data analysis. These efforts will facilitate the conduct of research in this proposal and will provide the expertise to support the Project Leaders. With the amalgamation of carcinogenesis models and genetically engineered mouse models in sphingolipids, this core is already evolving as a unique and enabling core that is critical for the success of the Program Project.