From planar chirality to matched and mismatched dendrimers

从平面手性到匹配和不匹配的树枝状聚合物

• 批准号: EP/C547322/1
• 负责人: Susan Gibson
• 金额: $ 15.87万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FC547322%2F1
• 关键词: planar; chirality; matched; mismatched; dendrimers

The demand for increasingly more efficient and effective pharmaceuticals needs to be met by increasingly more efficient and effective methods of making these molecules. Many pharmaceuticals are chiral, which means that they exist as two mirror images. These mirror images often behave quite differently in their interactions with the body's complex chemistry, and so it is important for safety and economic reasons to make pharmaceuticals in just one of its two forms i.e. the one which has the best clinical effect. One of the most efficient ways of doing this is by using a small amount of a chiral catalyst, ultimately derived from chirality created by nature, to generate large amounts of a key molecule en route to the target pharmaceutical. In this project we plan to use a series of reactions discovered in our laboratories, which enables us to rapidly create molecules containing previously difficult-to-access symmetries, to create new chiral catalysts. The catalysts will be tested in several key reactions and the most promising will be developed further so that they may ultimately be used in pharmaceutical manufacture.

对越来越高效和有效的药物的需求需要通过越来越高效和有效的制备这些分子的方法来满足。许多药物是手性的，这意味着它们以两个镜像存在。这些镜像在与人体复杂的化学物质相互作用时表现得非常不同，因此出于安全和经济原因，重要的是仅以其两种形式之一制造药物，即具有最佳临床效果的药物。最有效的方法之一是使用少量的手性催化剂，最终来源于自然产生的手性，以产生大量的关键分子，从而获得目标药物。在这个项目中，我们计划使用我们实验室中发现的一系列反应，这使我们能够快速创建包含以前难以获得的对称性的分子，以创建新的手性催化剂。催化剂将在几个关键反应中进行测试，最有前途的将进一步开发，以便最终用于制药。

项目成果

Synthesis of (+)- and (-)-Gossonorol and Cyclisation to Boivinianin B

• DOI: 10.1002/ejoc.201000391
• 发表时间: 2010-05-01
• 期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
• 影响因子: 2.8
• 作者: Abecassis, Keren;Gibson, Susan E.
• 通讯作者: Gibson, Susan E.

Synthesis of Enantioenriched Secondary and Tertiary Alcohols via Tricarbonylchromium(0) Complexes of Benzyl Allyl Ethers

苄基烯丙基醚的三羰基铬(0)配合物合成对映体富集的仲醇和叔醇

• DOI: 10.1002/ejoc.200900007
• 发表时间: 2009
• 期刊: European Journal of Organic Chemistry
• 影响因子: 2.8
• 作者: Abecassis K