Genetic Variation in Amphetamine Response

安非他明反应的遗传变异

• 批准号: 7483842
• 负责人: Ajna Hamidovic
• 金额: $ 6.04万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-27 至 2009-06-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7483842
• 关键词: Acute; Amphetamines; Attention deficit hyperactivity disorder; Basic Science; Behavioral; Candidate Disease Gene; Casein Kinase Iepsilon; Catechol O-Methyltransferase; Clinical; Cognition; Cognitive; DRD2 gene; Data Analyses; Dependence; Dose; Drug Addiction; Drug abuse; Funding; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Genotype; Goals; Grant; Human; Human Volunteers; Impulsive Behavior; Impulsivity; Individual; Investigation; Knowledge; Laboratories; Learning; Literature; Measures; Mediating; Methionine; Methyltransferase Gene; Moods; Mus; National Research Service Awards; Neurons; Patients; Performance; Pharmaceutical Preparations; Phenotype; Postdoctoral Fellow; Psychopharmacology; Public Health; Publications; Publishing; Purpose; Rate; Reading; Receptor Gene; Reporting; Request for Applications; Research; Research Personnel; Research Project Grants; Sampling; Scientist; Screening procedure; Source; Supervision; System; Testing; Training; Valine; Variant; Wit; base; career; design; dopamine D4 receptor; drug of abuse; healthy volunteer; improved; psychopharmacologic; receptor; research study; response; stimulant abuse; tool; training project

DESCRIPTION (provided by applicant): This NRSA F32 application requests two years of post doctoral support for Dr. Ajna Hamidovic to extend her training in research in human psychopharmacology. Specifically, she proposes to obtain training to study the genetic basis of responses to acute drugs, in the context of an ongoing NIH-funded research project (DA021336; PI Abraham Palmer; Co Investigator Harriet de Wit). The broad goal of this training application is to provide Dr. Hamidovic with the tools needed to launch an independent career as a research scientist in drug abuse research. Specifically, the candidate will receive training in all aspects of conducting a human psychopharmacological study with genetic variables. Her training will include courses, seminars and one-qnone reading sessions to provide a comprehensive knowledge of the relevant literature, as well as both the theoretical and methodological issues related to this type of research. She will learn all aspects of conducting the research including design, recruitment, screening, testing, supervision of assistants, management and analysis of data, and preparing results for publication and presentations. The specific aims of the research study are to investigate the genetic sources of variation in acute responses to damphetamine (0-20 mg) in healthy volunteers, in three domains: i) subjective or mood altering effects, ii) effects of the drug on impulsive behavior, and iii) effects of the drug on other measures of cognition. Subjects will be genotyped for polymorphisms in several genes that have been associated with each of these measures. The NIH-funded grant upon which this training project is based was designed to investigate the mood-altering effects, but Dr. Hamidovic will extend this investigation to also examine the effects of the drug on impulsive behaviors and measures of cognition. PUBLIC HEALTH RELEVANCE: The relevance of this study to public health is new information about the genetic variability in the quality of magnitide of subjective and behavioral responses to commonly abused drugs which may help researchers understand why some individuals are vulnerable to, or protected from, drug addiction.

描述（由申请人提供）：此 NRSA F32 申请要求为 Ajna Hamidovic 博士提供两年的博士后支持，以扩展她在人类精神药理学研究方面的培训。具体来说，她建议在 NIH 资助的一项正在进行的研究项目（DA021336；PI Abraham Palmer；联合研究员 Harriet de Wit）的背景下获得培训，以研究急性药物反应的遗传基础。此培训应用程序的总体目标是为 Hamidovic 博士提供作为药物滥用研究研究科学家开展独立职业所需的工具。具体来说，候选人将接受利用遗传变量进行人类精神药理学研究的各个方面的培训。她的培训将包括课程、研讨会和一对一阅读课程，以提供相关文献的全面知识，以及与此类研究相关的理论和方法问题。她将学习进行研究的各个方面，包括设计、招募、筛选、测试、助理监督、数据管理和分析，以及准备出版和演示的结果。该研究的具体目的是调查健康志愿者对丹非他明（0-20 mg）急性反应变异的遗传来源，涉及三个领域：i) 主观或情绪改变效应，ii) 药物对冲动行为的影响，以及 iii) 药物对其他认知指标的影响。将对受试者进行与这些测量中的每一个相关的几个基因的多态性基因分型。该培训项目所依据的美国国立卫生研究院 (NIH) 资助的赠款旨在研究改变情绪的影响，但哈米多维奇博士将扩展这项研究，以检查该药物对冲动行为和认知测量的影响。 公共健康相关性：这项研究与公共健康的相关性是关于对常见滥用药物的主观和行为反应的马格奈肽质量的遗传变异性的新信息，这可能有助于研究人员了解为什么某些人容易吸毒或免受吸毒成瘾。