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Late Luteal Phase Reactivity to Stress

黄体后期对应激的反应

基本信息

批准号：
10057230
负责人：
Ajna Hamidovic
金额：
$ 23.99万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-26 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10057230
关键词：
Acute Affect Affective Applications Grants Area Cardiovascular system Categories Clinical Cohort Studies Collection Complex Data Diagnosis Disease Enrollment Equation Estradiol Etiology Functional disorder Future Goals Heterogeneity High Prevalence Hormones Hydrocortisone Individual Intervention Kinetics Knowledge Laboratories Length Literature Longitudinal Studies Luteal Phase Measurement Mediating Menstrual cycle Menstruation Meta-Analysis Methodology Methods Modeling Moods Ovulation Participant Pathway interactions Periodicity Pharmacology Phase Physiological Pilot Projects Premenstrual syndrome Procedures Progesterone Protocols documentation Psychological Stress Psychosocial Stress Publishing Reading Research Research Design Research Personnel Role Sampling Schedule Serum Stress Stress Tests Structure Study models Symptoms Systems Analysis Testing Time Trier Social Stress Test Variant Woman Work acute stress aged base biological adaptation to stress clinical heterogeneity clinically relevant design endophenotype experience experimental study hypothalamic pituitary gonadal axis hypothalamic-pituitary-adrenal axis improved kinetic model physical symptom programs proliferative phase Menstrual cycle prospective psychologic psychological symptom reactivation from latency reproductive reproductive axis reproductive hormone response sound stress reactivity study population urinary

项目摘要

PROJECT SUMMARY/ABSTRACT Premenstrual Syndrome (PMS) is a psychiatric condition affecting approximately 20% of reproductive-aged women. Despite its high prevalence, very little is known about its etiology. We have designed a future study to show that variation in the reproductive hormone kinetics across the menstrual cycle leads to PMS and to clarify multi-domain pathways of this relationship. The model of this study includes an acute psychosocial stress reactivity component. Therefore, the proposed study will clarify the time within the menstrual cycle at which stress reactivity differs between women with PMS diagnosis and healthy controls. We hypothesize a blunted cortisol response in women with PMS diagnosis upon acute stress challenge during the late luteal phase of the menstrual cycle. Results of this research will advance our understanding of the physiological and psychological milieu which sensitizes susceptible women to be especially vulnerable to stress prior to menstruation. The proposed study will enroll one hundred and twenty healthy women with regular menstrual cycles. They will chart their symptoms, menstruation timing and ovulation for two menstrual cycles. This data will form the basis for PMS diagnosis and predictable bounds of menstrual cycle phases. In the third menstrual cycle, study participants will complete the Trier Social Stress Test session in the late luteal phase of the menstrual cycle. The hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, cardiovascular system and affective state will be evaluated at baseline and at seven time points following the stress procedure. Knowledge gained from this experiment will increase our understanding of acute stress reactivity specific to the study population, as well as collect key data for our long-term program of research, designed to reduce clinical heterogeneity in PMS.

项目总结/文摘

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Waist Circumference and Its Association With Premenstrual Food Craving: The PHASE Longitudinal Study.

DOI：
10.3389/fpsyt.2022.784316
发表时间：
2022
期刊：
FRONTIERS IN PSYCHIATRY
影响因子：
4.7
作者：
Dang, Nhan;Khalil, Dina;Sun, Jiehuan;Naveed, Aamina;Soumare, Fatimata;Hamidovic, Ajna
通讯作者：
Hamidovic, Ajna

Allopregnanolone Is Associated with a Stress-Induced Reduction of Heart Rate Variability in Premenstrual Dysphoric Disorder.

DOI：
10.3390/jcm12041553
发表时间：
2023-02-16
期刊：
JOURNAL OF CLINICAL MEDICINE
影响因子：
3.9
作者：
Hamidovic, Ajna;Davis, John;Soumare, Fatimata;Naveed, Aamina;Ghani, Yaseen;Semiz, Selma;Khalil, Dina;Wardle, Margaret
通讯作者：
Wardle, Margaret

Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women's Health Research.

DOI：
10.3390/metabo12100941
发表时间：
2022-10-04
期刊：
Metabolites
影响因子：
4.1
作者：
Hamidovic A;Soumare F;Naveed A;Davis J;Sun J;Dang N
通讯作者：
Dang N

Behavioral Symptomatology in the Premenstruum.

DOI：
10.3390/brainsci12070814
发表时间：
2022-06-22
期刊：
BRAIN SCIENCES
影响因子：
3.3
作者：
Nhan Dang;Khalil, Dina;Sun, Jiehuan;Naveed, Aamina;Soumare, Fatimata;Nusslock, Robin;Hamidovic, Ajna
通讯作者：
Hamidovic, Ajna

Periovulatory Subphase of the Menstrual Cycle Is Marked by a Significant Decrease in Heart Rate Variability.