The Nucleus Accumbens and Relative Reward

伏核和相对奖励

• 批准号: 7385999
• 负责人: ROBERT A WHEELER
• 金额: $ 5.2万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-24 至 2009-03-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7385999
• 关键词: Animals; Arts; Behavior; Behavioral; Behavioral Paradigm; Cells; Child; Cocaine; Consumption; DSM-IV; Diagnosis; Disease; Drug Addiction; Event; Fire - disasters; Flavoring; Foundations; Goals; Grapes; Individual; Light; Measurement; Mediating; Neurons; Nucleus Accumbens; Oranges; Pattern; Pharmaceutical Preparations; Population; Property; Rate; Rattus; Reaction; Recreation; Relative (related person); Rewards; Saccharin; Scanning; Self-Administered; Stimulus; Structure; Substance Addiction; Substance abuse problem; Taste Perception; Techniques; Training; awake; design; drug of abuse; drug reward; experience; neglect; neural circuit; neuromechanism; relating to nervous system; research study; response; time use

DESCRIPTION (provided by applicant): The nucleus accumbens (NAc) is an important neural structure involved in mediating the reinforcing actions of natural rewards as well as drugs of abuse, such as cocaine. Indeed, individual populations of NAc cells selectively encode for cocaine or natural rewards. However, experiences with powerful rewards impact behavioral reactions to lesser rewards and ultimately, natural rewards are devalued as they are compared to drugs of abuse. In fact, dysfunctional reward comparison behavior is a sufficient criterion for the diagnosis of Substance Abuse as defined by the DSM-IV, and one of the criteria for the diagnosis of Substance Dependence. Unfortunately, the neural foundation of the pathological interaction of drugs of abuse and natural rewards remains unclear. The PI will investigate these interactions in real time using electrophysiological and electrochemical recordings in the NAc that allow for measurements of cell firing and DA release for the natural reward that predicts access to the drug of abuse as well as for the drug reward itself. These studies will shed light on the neural substrate of reward comparison.

描述（由申请人提供）： 伏隔核 (NAc) 是一种重要的神经结构，参与调节自然奖励以及滥用药物（如可卡因）的强化作用。事实上，NAc 细胞的个体群体选择性地编码可卡因或自然奖励。然而，获得强大奖励的经历会影响对较小奖励的行为反应，最终，与滥用药物相比，自然奖励会贬值。事实上，功能失调的奖励比较行为是 DSM-IV 定义的药物滥用诊断的充分标准，也是药物依赖诊断的标准之一。不幸的是，滥用药物和自然奖励之间的病理相互作用的神经基础仍不清楚。 PI 将使用 NAc 中的电生理学和电化学记录来实时研究这些相互作用，从而测量细胞放电和 DA 释放，以预测获得滥用药物的自然奖励以及药物奖励本身。这些研究将揭示奖励比较的神经基础。

项目成果

The neuroscience of pleasure. Focus on "Ventral pallidum firing codes hedonic reward: when a bad taste turns good".

快乐的神经科学。

• DOI: 10.1152/jn.00727.2006
• 发表时间: 2006
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Wheeler,RobertA;Carelli,ReginaM
• 通讯作者: Carelli,ReginaM