nano-Particle Resonance Imaging

纳米粒子共振成像

• 批准号: EP/D028027/1
• 负责人: Mi Wang
• 金额: $ 36.21万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD028027%2F1
• 关键词: nano; Particle; Resonance; Imaging

This is a strong industrial demand for on-line characterisation of particle size and concentration distribution in chemical engineering processes, e.g. the precipitation or crystallisation process in pharmaceutical or nuclear fuel industries. The currently available techniques are mostly in the type of sampling and off-line analysis. There is no on-line device for nano-particle characterisation. Another common features of these imaging systems is that they measure the same form of energy as the type of the excitation. Therefore, it may have difficulties in the separation of the excitation and responding variables in the use of the frequency domain analysis. The resolution of this type imaging methods is also constrained by their physical limitation, e.g. the wavelength and intensity of the excitation signal in optical imaging methods.The size and density of particles are normally different from those of ions in colloids. The distribution of charges carried by ions is in exponential decay with the distance from the particle surface. Under an external force, they will move with different acceleration and terminal speeds, or vibrate with different amplitudes and phase lags in the case of an alternating force. The differences in the acceleration and terminal speeds, or the amplitudes and phase lags reflect the properties of particles' zeta-potential, size and density. The research proposed is to utilise the unique features of particles in colloids for indirect imaging of characteristic distribution of nano-particles. The indirect imaging method is based on the concepts ofa)the vibration of electric charged particles in colloids energized by an external force;b)the energy conversion due to the vibration of charged particles;c)the resonance principle for maximising the signal strength;d)the tomographic reconstruction to position the vibration. The proposed PRI method has unique advantages at a)the separation of excitation and responding variables;b)the correlation of particle size and density;c)the reflection of particle-particle interaction;d)the resolution selective based on either excitation or responding field.Through the appreciated approach, the proposed Particle Resonance Imaging (PRI) may lead to a new indirect imaging method and provide a highly desirable and powerful on-line particle analysis tool to meet the emergent requirement from pharmaceutical, nuclear and other wide range industries.

这是对化学工程过程中颗粒尺寸和浓度分布在线表征的强烈工业需求。制药或核燃料工业中的沉淀或结晶过程。目前可用的技术主要是采样和离线分析类型。没有用于纳米颗粒表征的在线设备。这些成像系统的另一个共同特征是它们测量与激发类型相同形式的能量。因此，在使用频域分析时，激励变量和响应变量的分离可能存在困难。这种类型成像方法的分辨率也受到其物理限制的限制，例如光学成像方法中激发信号的波长和强度。颗粒的尺寸和密度通常与胶体中离子的尺寸和密度不同。离子携带的电荷分布随着距粒子表面的距离呈指数衰减。在外力作用下，它们会以不同的加速度和终端速度运动，或者在交变力的情况下以不同的幅度和相位滞后振动。加速度和终端速度的差异，或者振幅和相位滞后的差异反映了粒子的zeta电位、尺寸和密度的特性。该研究旨在利用胶体中颗粒的独特特征对纳米颗粒的特征分布进行间接成像。间接成像方法基于以下概念：a）受外力激励的胶体中带电粒子的振动；b）带电粒子振动引起的能量转换；c）最大化信号强度的共振原理；d）断层扫描重建以定位振动。所提出的 PRI 方法在以下方面具有独特的优势：a) 激励和响应变量的分离；b) 颗粒尺寸和密度的相关性；c) 颗粒间相互作用的反映；d) 基于激励或响应场的分辨率选择性。 满足制药、核能和其他广泛行业的紧急需求。

项目成果

An Experimental Investigation of Ionic Vibration Potential Sensing in Electrolytes

电解质中离子振动电势传感的实验研究

• DOI: 10.1016/j.proeng.2015.01.107
• 发表时间: 2015
• 期刊: Procedia Engineering
• 作者: Hosseini M

Electrical Impedance Spectroscopy Study on Charged Particles in Crystallisation Processes

结晶过程中带电粒子的电阻抗谱研究

• 发表时间: 2009
• 作者: Y Zhao

Towards Nano-Particle Resonance Imaging for Use in Breast Cancer Imaging

用于乳腺癌成像的纳米粒子共振成像

• 发表时间: 2009
• 作者: G Peng

Characterisation of Crystallisation Processes with Electrical Impedance Spectroscopy

用电阻抗谱表征结晶过程

• 发表时间: 2009
• 作者: Y Zhao

Experimental study on dielectric relaxation of SiO2 nano-particle suspensions for developing a particle characterization method based on electrical impedance spectroscopy

SiO2 纳米颗粒悬浮液介电弛豫的实验研究，用于开发基于电阻抗光谱的颗粒表征方法

• DOI: 10.1016/j.powtec.2015.04.070
• 发表时间: 2015-09
• 期刊: Powder Technology
• 影响因子: 5.2
• 作者: Y L Zhao;M Wang
• 通讯作者: M Wang