Tissue and Specimen Core

样本核心为项目1 - 5以及未来的试点和 发展项目。它的设计是为了满足这些项目的需要，并作为一个立场- 与其他SPORE合作的唯一资源。这一核心将提供一个组织良好， 样本采集、储存、分发和相关临床/研究信息的标准化系统 这是基于二十多年的经验。会有一致性和质量 确保组织标本的病理分析。此外，集中管理 这些标本将根据一个调查小组确定的优先次序进行分发 熟悉我们所有的孢子研究工作。本核心组的操作分为5个部分： 1.标本采集、处理、质量控制、储存和数据库登录。 2.一项开发计划，以不断提高我们获得组织的质量和效率 样品和衍生产品。 3.前列腺癌异种移植维持、开发和研究计划。 4.实验室服务，包括泌尿科医生对组织的解读和组织定位研究 病理学家、免疫组织化学（IHC）、定量RT-PCR和免疫测定，即PSA，以及 组织培养核心还将使用我们的异种移植资源进行临床前研究， 5.一项行政计划，从少数民族患者中获取样本，优先分配 标本，进行质量控制计划，确保患者保密并遵守IRB 要求，并与其他前列腺孢子相互作用。 翻译研究的表现要求研究者能够很好地利用 记录的临床标本和相关生物模型。指导生物标本的研究人员 核心有几十年的经验，认识到这些需求，并提供这种服务，不仅对当地 调查人员，但那些谁要求标本在世界范围内的基础上。例如， 我们的快速尸检项目的标本（例如前列腺癌骨转移）和我们的LuCaP系列 前列腺癌异种移植物已经在国际上分布。在这次更新中，这种与我们的互动 自己的SPORE调查人员，与其他SPORE调查人员的合作以及与非SPORE调查人员的合作， SPORE调查人员将是一个高度优先事项。这将真正加强核武器的翻译方面 前列腺癌的症状

The Specimen Core provides part of the infrastructure support for Projects 1 - 5 as well as for future pilot and developmental projects. It has been designed to meet the needs of these projects plus serve as a stand- alone resource for collaborative efforts with other SPOREs. This Core will provide a well-organized and standardized system of specimen collection, storage, distribution and related clinical/research information dissemination that is based on over two decades of experience. There will be consistency and quality assurance in the pathological analysis of tissue specimens. Furthermore, the centralized management of the specimens will facilitate their distribution based upon the priorities defined by a panel of investigators familiar with all of our SPORE research endeavors. The operations of this Core group into 5 components: 1. Specimen acquisition, processing, quality control, storage and accessioning into databases. 2. A development program to continually improve the quality and efficiency with which we obtain tissue samples and derivative products. 3. A prostate cancer xenograft maintenance, development and study program. 4. Laboratory services, including interpretation of tissues and tissue localization studies by a urologic pathologist, immunohistochemistry (IHC), quantitative RT-PCR, and immunoassays, i.e. PSA, and tissue culture. The Core will also perform pre-clinical studies using our xenograft resources, and 5. An administrative program to obtain samples from minority patients, prioritize the distribution of specimens, conduct a quality control program, ensure patient confidentiality and compliance with IRB requirements, and to interact with other prostate SPOREs. The performance of translational research mandates that investigators have ready access to well documented clinical specimens and relevant biological models. The investigators directing the Biospecimen Core have decades of experience in recognizing these needs and providing such services not only to local investigators but to those who request specimens on a world-wide basis. For example, samples of specimens from our rapid autopsy program (e.g. prostate cancer bone metastases) and our LuCaP series of prostate cancer xenografts have been distributed internationally. In this renewal, such interactions with our own SPORE investigators, those collaborations with other SPORE investigators and collaborations with non- SPORE investigators will be a high priority. This will truly enhance the translational aspects of the NW Prostate Cancer SPORE.