Tissue and Specimen Core

样本核心为项目1-5以及未来的试点和 发展项目。它是为满足这些项目的需求而设计的，并作为一个展台- 与其他孢子合作的唯一资源。这一核心将提供一个组织良好的 标本收集、储存、分发和相关临床/研究信息的标准化系统 以二十多年的经验为基础的传播。将会有一致性和质量 组织标本病理分析方面的保证。此外，集中管理 标本将根据一个调查小组确定的优先顺序为其分发提供便利 熟悉我们所有的孢子研究工作。此核心组的运营分为5个组成部分： 1.标本的获取、处理、质量控制、储存和进入数据库。 2.不断提高我们获取组织的质量和效率的发展计划 样品和衍生产品。 3.前列腺癌异种移植的维持、开发和研究计划。 4.实验室服务，包括由泌尿科医生解释组织和组织定位研究 病理学家、免疫组织化学(IHC)、定量RT-PCR和免疫分析，即PSA，以及 组织培养。Core还将利用我们的异种移植资源进行临床前研究，以及 5.从少数族裔患者那里获取样本的行政计划，优先分配 样本，执行质量控制程序，确保患者保密并遵守IRB 要求，并与其他前列腺孢子相互作用。 翻译研究的绩效要求调查人员能够随时接触到油井 记录了临床标本和相关的生物模型。指导生物质谱仪的研究人员 CORE在认识到这些需求并提供此类服务方面拥有数十年的经验，不仅是为当地 调查人员，而是那些在世界范围内索要标本的人。例如，以下示例 来自我们的快速尸检计划的样本(例如前列腺癌骨转移)和我们的LuCaP系列 前列腺癌异种移植已经在国际上分布。在这次更新中，与我们的 自己的孢子调查员，与其他孢子调查员的合作，以及与非 孢子调查员将是重中之重。这将真正增强NW的翻译方面 前列腺癌孢子。

The Specimen Core provides part of the infrastructure support for Projects 1 - 5 as well as for future pilot and developmental projects. It has been designed to meet the needs of these projects plus serve as a stand- alone resource for collaborative efforts with other SPOREs. This Core will provide a well-organized and standardized system of specimen collection, storage, distribution and related clinical/research information dissemination that is based on over two decades of experience. There will be consistency and quality assurance in the pathological analysis of tissue specimens. Furthermore, the centralized management of the specimens will facilitate their distribution based upon the priorities defined by a panel of investigators familiar with all of our SPORE research endeavors. The operations of this Core group into 5 components: 1. Specimen acquisition, processing, quality control, storage and accessioning into databases. 2. A development program to continually improve the quality and efficiency with which we obtain tissue samples and derivative products. 3. A prostate cancer xenograft maintenance, development and study program. 4. Laboratory services, including interpretation of tissues and tissue localization studies by a urologic pathologist, immunohistochemistry (IHC), quantitative RT-PCR, and immunoassays, i.e. PSA, and tissue culture. The Core will also perform pre-clinical studies using our xenograft resources, and 5. An administrative program to obtain samples from minority patients, prioritize the distribution of specimens, conduct a quality control program, ensure patient confidentiality and compliance with IRB requirements, and to interact with other prostate SPOREs. The performance of translational research mandates that investigators have ready access to well documented clinical specimens and relevant biological models. The investigators directing the Biospecimen Core have decades of experience in recognizing these needs and providing such services not only to local investigators but to those who request specimens on a world-wide basis. For example, samples of specimens from our rapid autopsy program (e.g. prostate cancer bone metastases) and our LuCaP series of prostate cancer xenografts have been distributed internationally. In this renewal, such interactions with our own SPORE investigators, those collaborations with other SPORE investigators and collaborations with non- SPORE investigators will be a high priority. This will truly enhance the translational aspects of the NW Prostate Cancer SPORE.