Biospeciman Core

生物质学家核心(核心A)为项目1-3提供部分基础设施支持。此核心 将提供一个组织良好和标准化的标本收集、储存、分发和管理系统 基于二十多年经验的相关临床/研究信息传播。那里 将在组织标本的病理分析中保持一致性和质量保证。生物菌素 CORE还参与了一大系列前列腺癌异种移植株的维护 核心调查员。这些异种移植物被POI调查人员用于许多研究，每个 研究由核心人员监督。总体而言，这个核心小组的运营分为5个组成部分： 1.标本的获取、处理、质量控制、储存和进入数据库； 2.不断提高我们获取组织的质量和效率的发展计划 样品和衍生产品； 3.前列腺癌异种移植的维持、开发和研究计划。 4.实验室服务，包括由泌尿科医生解释组织和组织定位研究 病理学家、免疫组织化学(IHC)、定量RT-PCR和免疫分析，即PSA和组织 文化。该中心还将利用我们的异种移植资源进行临床前研究；以及 5.从少数族裔患者那里获取样本的行政计划，优先分配 样本，执行质量控制程序，并确保患者的机密性和遵守IRB 要求。此外，该中心还为所有项目调查人员提供生物统计学支持。 本计划项目中详细说明的每个研究项目的执行情况要求 调查人员已经准备好获取有充分文件记录的临床标本和相关的生物模型。这个 领导Biospecimen Core的研究人员也将其作为一项政策，以提供过量的前列腺癌 在世界范围内向非PPG调查人员提供标本资源。总体而言，Biospecimen核心是一个 该P01计划项目的关键组成部分。 相关性(请参阅说明)： Biosecimen核心不是假设驱动的，但它是这个POI的基本组件，使 调查团队进行假设驱动的项目。没有足够的标本和肿瘤 无论是数量上还是质量上的模型，这些研究人员进行的科学研究都不可能是稳健的。这 CORE确保它们是，而且还为数据分析提供出色的统计支持。

The Biospecimen Core (Core A) provides part of the infrastructure support for Projects 1-3. This Core will provide a well-organized and standardized system of specimen collection, storage, distribution and related clinical/research information dissemination that is based on over two decades of experience. There will be consistency and quality assurance in the pathological analysis of tissue specimens. The Biospecimen Core is also involved in the maintenance of a large series of prostate cancer xenograft lines developed by Core investigators. These xenografts are used for a number of studies by the POI investigators and each study is overseen by Core personnel. Overall, the operations of this Core group into 5 components: 1. Specimen acquisition, processing, quality control, storage and accessioning into databases; 2. A development program to continually improve the quality and efficiency with which we obtain tissue samples and derivative products; 3. A prostate cancer xenograft maintenance, development and study program. 4. Laboratory services, including interpretation of tissues and tissue localization studies by a urologic pathologist, immunohistochemistry (IHC), quantitative RT-PCR, and immunoassays, i.e. PSA, and tissue culture. The Core will also perform pre-clinical studies using our xenograft resources; and 5. An administrative program to obtain samples from minority patients, prioritize the distribution of specimens, conduct a quality control program, and to ensure patient confidentiality and compliance with IRB requirements. Furthermore, the Core provides biostatistical support to all of the project investigators. The performance of each of the research projects detailed in this program project mandates that investigators have ready access to well documented clinical specimens and relevant biological models. The investigators directing the Biospecimen Core also make it a policy to provide excess prostate cancer specimen resources to non-PPG investigators on a world-wide basis. Overall, the Biospecimen Core is a critical component of this P01 program project. RELEVANCE (See instructions): The Biospecimen Core is not hypothesis driven yet it is an essential component of this POI that enables the investigative teams to conduct hypothesis driven projects. Without adequate specimens and tumor models, both in quantity and quality, the science conducted by these investigators can not be robust. This Core assures that they are and futhermore provides outstanding statistical support for analyses of data.