Biospeciman Core

生物样本核心（核心A）为项目1-3提供部分基础设施支持。这一核心 将提供一个组织良好和标准化的标本采集、储存、分发和 基于二十多年经验的相关临床/研究信息传播。那里 将是组织标本病理分析的一致性和质量保证。生物标本 核心也参与了维护一个大系列的前列腺癌异种移植系开发的 核心调查员。这些异种移植物被POI研究者用于许多研究， 研究由核心人员监督。总体而言，本核心组的业务分为5个组成部分： 1.标本采集、处理、质量控制、储存和数据库登录; 2.一项开发计划，以不断提高我们获得组织的质量和效率 样品和衍生产品; 3.前列腺癌异种移植维持、开发和研究计划。 4.实验室服务，包括泌尿科医生对组织的解读和组织定位研究 病理学家、免疫组织化学（IHC）、定量RT-PCR和免疫测定，即PSA和组织 文化核心还将使用我们的异种移植资源进行临床前研究; 5.一项行政计划，从少数民族患者中获取样本，优先分配 标本，进行质量控制计划，并确保患者保密性和符合IRB 要求.此外，核心小组还向所有项目调查人员提供生物统计支持。 本计划项目中详细介绍的每个研究项目的绩效要求， 研究人员可随时取得有充分记录的临床样本和有关的生物模型。的 指导生物样本核心的研究人员也制定了一项政策， 在全球范围内向非PPG研究者提供样本资源。总的来说，生物标本核心是一个 P01项目的关键组成部分。 相关性（参见说明）： 生物样本核心不是假设驱动的，但它是该POI的重要组成部分， 调查小组进行假设驱动的项目。没有足够的标本和肿瘤 模型，无论是在数量和质量上，这些研究人员进行的科学不可能是强大的。这 核心保证，他们是和future提供出色的统计支持的数据分析。

The Biospecimen Core (Core A) provides part of the infrastructure support for Projects 1-3. This Core will provide a well-organized and standardized system of specimen collection, storage, distribution and related clinical/research information dissemination that is based on over two decades of experience. There will be consistency and quality assurance in the pathological analysis of tissue specimens. The Biospecimen Core is also involved in the maintenance of a large series of prostate cancer xenograft lines developed by Core investigators. These xenografts are used for a number of studies by the POI investigators and each study is overseen by Core personnel. Overall, the operations of this Core group into 5 components: 1. Specimen acquisition, processing, quality control, storage and accessioning into databases; 2. A development program to continually improve the quality and efficiency with which we obtain tissue samples and derivative products; 3. A prostate cancer xenograft maintenance, development and study program. 4. Laboratory services, including interpretation of tissues and tissue localization studies by a urologic pathologist, immunohistochemistry (IHC), quantitative RT-PCR, and immunoassays, i.e. PSA, and tissue culture. The Core will also perform pre-clinical studies using our xenograft resources; and 5. An administrative program to obtain samples from minority patients, prioritize the distribution of specimens, conduct a quality control program, and to ensure patient confidentiality and compliance with IRB requirements. Furthermore, the Core provides biostatistical support to all of the project investigators. The performance of each of the research projects detailed in this program project mandates that investigators have ready access to well documented clinical specimens and relevant biological models. The investigators directing the Biospecimen Core also make it a policy to provide excess prostate cancer specimen resources to non-PPG investigators on a world-wide basis. Overall, the Biospecimen Core is a critical component of this P01 program project. RELEVANCE (See instructions): The Biospecimen Core is not hypothesis driven yet it is an essential component of this POI that enables the investigative teams to conduct hypothesis driven projects. Without adequate specimens and tumor models, both in quantity and quality, the science conducted by these investigators can not be robust. This Core assures that they are and futhermore provides outstanding statistical support for analyses of data.