Biospeciman Core

生物样本核心

基本信息

批准号：
8518251
负责人：
ROBERT Louis VESSELLA
金额：
$ 50.28万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-05-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8518251
关键词：
Address African American Aliquot Androgen Receptor Antibodies Aspirate substance Autopsy Back Bioinformatics Biological Assay Biological Markers Biological Models Biological Preservation Biometry Biopsy Bone Marrow Cancer Research Project Cells Cellular Structures Censuses Charge Clinic Clinical Clinical Data Clinical Research Clinical Trials Collaborations Communication Complementary DNA Computer software Confidentiality Confidentiality of Patient Information Consent Country DNA Data Data Analyses Data Quality Databases Development Doctor of Philosophy Ensure Epithelial Exercise Foundations Fred Hutchinson Cancer Research Center Freezing Frozen Sections Funding Future Gel Gel Chromatography Gender Gene Expression Generations Genes Gleason Grade for Prostate Cancer Glycoproteins Goals Grant Health Insurance Portability and Accountability Act Hematoxylin and Eosin Staining Method Histologic Human Resources Image Immunoassay Immunohistochemistry In Situ Hybridization Individual Industry Information Dissemination Institutes Institutional Review Boards Instruction LNCaP Laboratories Lasers Leadership Link Liquid substance Location Lymphocyte Maintenance Malignant neoplasm of prostate Marrow Metastatic Neoplasm to the Bone Methodology Methods Minority Modeling Monitor Mus Neoadjuvant Therapy Neoplasm Circulating Cells Neoplasm Metastasis Online Systems Operative Surgical Procedures PC3 cell line Pathologic Pathologist Patients Performance Peripheral Blood Lymphocyte Phenotype Plasma Policies Predictive Value Process Program Development Program Research Project Grants Progress Reports Prostate Prostate specific antigen measurement Protocols documentation Quality Control Quantum Dots RNA RNA Degradation RNA, Ribosomal, 18S Radical Prostatectomy Records Recurrence Research Research Infrastructure Research Personnel Research Project Grants Resource Sharing Resources Reverse Transcriptase Polymerase Chain Reaction Sampling Science Sepharose Serial Passage Series Serum Services Slide Sorting - Cell Movement Specific Pathogen Frees Specimen Specimen Handling Staging Staining method Stains Stem cells System Techniques Tissue Microarray Tissue Sample Tissues Training Tumor Tissue United States National Institutes of Health Work Xenograft Model Xenograft procedure abstracting anticancer research base cDNA Expression cancer specimen resource compliance behavior cost cost effectiveness crosslink experience germ free condition human tissue immunoreactivity improved interest laser capture microdissection neoplastic cell novel operation peripheral blood preclinical study prognostic programs quality assurance relational database repository research and development research study response sample collection sample fixation serum PSA time interval tissue culture tool tumor urologic user-friendly

项目摘要

The Biospecimen Core (Core A) provides part of the infrastructure support for Projects 1-3. This Core will provide a well-organized and standardized system of specimen collection, storage, distribution and related clinical/research information dissemination that is based on over two decades of experience. There will be consistency and quality assurance in the pathological analysis of tissue specimens. The Biospecimen Core is also involved in the maintenance of a large series of prostate cancer xenograft lines developed by Core investigators. These xenografts are used for a number of studies by the POI investigators and each study is overseen by Core personnel. Overall, the operations of this Core group into 5 components: 1. Specimen acquisition, processing, quality control, storage and accessioning into databases; 2. A development program to continually improve the quality and efficiency with which we obtain tissue samples and derivative products; 3. A prostate cancer xenograft maintenance, development and study program. 4. Laboratory services, including interpretation of tissues and tissue localization studies by a urologic pathologist, immunohistochemistry (IHC), quantitative RT-PCR, and immunoassays, i.e. PSA, and tissue culture. The Core will also perform pre-clinical studies using our xenograft resources; and 5. An administrative program to obtain samples from minority patients, prioritize the distribution of specimens, conduct a quality control program, and to ensure patient confidentiality and compliance with IRB requirements. Furthermore, the Core provides biostatistical support to all of the project investigators. The performance of each of the research projects detailed in this program project mandates that investigators have ready access to well documented clinical specimens and relevant biological models. The investigators directing the Biospecimen Core also make it a policy to provide excess prostate cancer specimen resources to non-PPG investigators on a world-wide basis. Overall, the Biospecimen Core is a critical component of this P01 program project. RELEVANCE (See instructions): The Biospecimen Core is not hypothesis driven yet it is an essential component of this POI that enables the investigative teams to conduct hypothesis driven projects. Without adequate specimens and tumor models, both in quantity and quality, the science conducted by these investigators can not be robust. This Core assures that they are and futhermore provides outstanding statistical support for analyses of data.

BiospeCemen Core（核心A）为1-3的项目提供了一部分基础架构支持。这个核心将提供一个组织良好且标准化的标本收集，存储，分销和相关的临床/研究信息传播基于超过二十年的经验。那里在组织标本的病理分析中将是一致性和质量保证。生物测量核心还参与了由一系列前列腺癌异种移植线的维护核心调查员。这些异种移植物用于POI研究者的许多研究，每个研究研究由核心人员监督。总体而言，该核心组的运营分为5个组成部分： 1。采集，处理，质量控制，存储和登录到数据库中； 2。开发计划，以不断提高我们获得组织的质量和效率样品和衍生产品； 3。前列腺癌异种移植，发展和研究计划。 4。实验室服务，包括通过泌尿科对组织和组织定位研究的解释病理学家，免疫组织化学（IHC），定量RT-PCR和免疫测定，即PSA和组织文化。核心还将使用我们的异种移植资源进行临床前研究。和 5。一项行政计划，以获取少数族裔患者的样本，优先分配标本，进行质量控制计划，并确保患者的机密性和遵守IRB 要求。此外，核心为所有项目调查人员提供了生物统计学支持。该计划项目中详细介绍的每个研究项目的绩效都规定研究人员已经准备好访问已记录良好的临床标本和相关的生物学模型。这指导生物循环核心的调查人员也使提供多余的前列腺癌的政策是一项政策在世界范围内，标本资源向非PPG调查人员提供给非PPG调查人员。总体而言，生物晶体核心是此P01程序项目的关键组成部分。相关性（请参阅说明）：生物播种核心不是假设驱动的，但它是该POI的重要组成部分，可以调查团队进行假设驱动的项目。没有足够的标本和肿瘤在数量和质量方面，这些研究者进行的科学都无法稳健。这核心确保它们是，Futhermore为数据分析提供了出色的统计支持。