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ASYMMETRIC TRANSFER HYDROGENATION USING TETHERED LIGANDS

使用束缚配体的不对称转移氢化

基本信息

批准号：
EP/D031168/1
负责人：
Martin Wills
金额：
$ 23.77万
依托单位：
University of Warwick
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FD031168%2F1
关键词：
ASYMMETRIC TRANSFER HYDROGENATION USING TETHERED

项目摘要

Many molecules can exist in one of a pair of mirror-images, or 'enantiomers', rather like a pair of hands. Many of the molecules which make up biological organisms (microbes, plants, animals, us...) exist only in a single enantiomer form. These include amino acids (which are used to make peptides and enzymes in the body), carbohydrates, and the chain of DNA (which also has a spiral with a single handedness). Anything we consume interacts with the molecules which make up our bodies. Because the molecules in our bodies are 'one handedness' then each of a pair of enantiomers will interact differently. As a result, there are many cases of enantiomeric molecules where one enantiomer has beneficial properties whilst the other may have none at all, or even be harmful. As a result, any new pharmaceutical compounds, or indeed any new molecular entities with the potential to exist as enantiomers, must be preparable in single-enantiomer form. This is challenging for the synthetic chemist, but represents one of the most important objectives of contemporary synthetic chemistry.In previous work, we have developed catalysts for the conversion of readily-available starting materials (ketones) into predominantly one handedness of an enantiomeric product (alcohols). In some cases the selectivity is very high. However in other cases it is not. In this proposal, we propose several modifications to our catalysts which are predicted to make them more appropriate for the reduction of a much wider series of substrates, thus increasing their overall usefulness. In the long term our objective is to develop ways of modifying our catalysts so that they can be employed for the selective synthesis of pure enantiomers of any desired target. This project represents an important step towards this objective.

许多分子可以存在于一对镜像或“对映体”中的一个中，就像一双手一样。构成生物有机体的许多分子（微生物，植物，动物，我们...）仅以单一对映体形式存在。这些包括氨基酸（用于在体内制造肽和酶），碳水化合物和DNA链（也有一个单螺旋）。我们消耗的任何东西都与组成我们身体的分子相互作用。因为我们体内的分子是“单手性”的，所以一对对映体中的每一个都将以不同的方式相互作用。因此，存在对映体分子的许多情况，其中一种对映体具有有益的性质，而另一种对映体可能根本没有或甚至是有害的。因此，任何新的药物化合物，或实际上任何可能作为对映异构体存在的新分子实体，必须以单一对映异构体形式可拆分。这是具有挑战性的合成化学家，但代表了当代合成化学的最重要的目标之一。在以前的工作中，我们已经开发出催化剂转化容易获得的起始材料（酮）主要是一个手性的对映体产品（醇）。在某些情况下，选择性非常高。然而，在其他情况下，它不是。在这个提议中，我们提出了几个修改我们的催化剂，预计使它们更适合于更广泛的一系列底物的还原，从而提高其整体的有用性。从长远来看，我们的目标是开发改性我们的催化剂的方法，使它们可以用于选择性合成任何所需目标的纯对映体。该项目是朝着这一目标迈出的重要一步。