The Strong Heart Study, Phase V

强心脏研究，第五阶段

• 批准号: 7413285
• 负责人: ELISA TAN LEE
• 金额: $ 213.02万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7413285
• 关键词: Accounting; Acute-Phase Proteins; Address; Age; Alaska Native; American; American Indians; Ankle; Area; Arizona; Arteries; Atherosclerosis; Biology; Blood Pressure; Blood Vessels; Body mass index; Budgets; C-reactive protein; Candidate Disease Gene; Cardiac; Cardiovascular Diseases; Cardiovascular system; Carotid Artery Plaques; Cell Adhesion; Cell Adhesion Molecules; Cerebrum; Cessation of life; Chromosomes; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 4; Chronic; Clinical; Cohort Studies; Communities; Condition; Coronary; DNA Resequencing; Data; Data Analyses; Diabetes Mellitus; Disease; Dyslipidemias; EFRAC; Employee Strikes; End Point; Epidemic; Ethnic group; Evaluation; Event; Extended Family; Factor Analysis; Family; Family Study; Family member; Female; Follow-Up Studies; Functional disorder; Funding; Gender; Genes; Genetic; Genetic Polymorphism; Genetic Transcription; Genome Scan; Genotype; Geographic Locations; Glucose; Goals; Health; Heart; Heart Diseases; Heart Hypertrophy; Height; Heritability; High Prevalence; Hyperglycemia; Immune system; In Vitro; Incidence; Individual; Inflammation; Insulin; Insulin Resistance; Interleukin-6; Investigation; Kidney Diseases; Lead; Learning; Left Ventricular Hypertrophy; Left Ventricular Mass; Life Expectancy; Localized; Longevity; Longitudinal Studies; Mannose Binding Lectin; Mannose-Binding Lectins; Maps; Measurement; Measures; Medial; Medical Surveillance; Meta-Analysis; Metabolic; Methods; Morbidity - disease rate; Natural Immunity; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Numbers; Obesity; Oklahoma; Participant; Pathway interactions; Peripheral; Peroxisome Proliferators; Phase; Phenotype; Plasma; Plasminogen Activator Inhibitor 1; Population; Prevalence; Prevention strategy; Principal Investigator; Public Health; Quantitative Trait Loci; Range; Rate; Research; Research Personnel; Risk; Risk Factors; Running; Screening procedure; Signal Transduction; Single Nucleotide Polymorphism; Stroke; Survivors; Syndrome; Testing; Therapeutic; Thick; Time; Ultrasonography; Variant; Vascular Diseases; Weight; Work; abstracting; age effect; age group; base; cardiovascular disorder risk; cardiovascular risk factor; cohort; cost; cytokine; design; diabetes mellitus genetics; diabetic; family genetics; field study; follow-up; gene function; genetic analysis; genetic linkage analysis; hydroxy-aluminum polymer; improved; indexing; insulin sensitivity; interest; male; member; mortality; novel; pre-clinical; programs; thrombospondin 4; toll-like receptor 4; trait; trend; young adult

DESCRIPTION (provided by applicant): There is an epidemic of cardiovascular disease (CVD) among American Indians. The Strong Heart Study (SHS) has been examining CVD and its risk factors by conducting a longitudinal cohort study and a family genetic study among 13 communities in 3 geographic areas (Arizona, the Dakotas, and Oklahoma). This application proposes to extend the SHS to pursue the following aims: 1) Expand the genetic studies that will emphasize the genome scan approach, but also include investigation of carefully selected candidate genes. The completed genome scan of 3776 members from 94 extended families will be used to identify quantitative trait loci and narrow the regions of interest by fine mapping. We also will examine a selected number of candidate genes that are difficult to exclude on the basis of linkage studies, but are of potential importance to vascular disease. 2) Continue the mortality and morbidity surveillance of the original cohort (approximately 2859 male and female survivors, ages 60 - 89 years) and to initiate annual mortality surveillance and limited morbidity follow-up of the non-cohort family members. 3) Re-examine the family members so that changes in risk factors can be analyzed and genetic effects on changes estimated. Advantages of the SHS include: 1) It provides health data on an underserved ethnic group. 2) It is the largest, longest longitudinal study in the US of CVD and its risk factors in individuals with diabetes. 3) Data from cardiac, carotid, and popliteal ultrasound measures will substantially improve understanding of mechanisms of vascular disease in diabetes and the genetics of CVD. 4) This population includes a group, in which the epidemic of obesity and diabetes has impacted people at very young ages, permitting analysis of genetic and environmental effects on these conditions with limited confounding by age effects. SHS will lead to valuable therapeutic and prevention strategies for this and other populations in the US and the world, where the epidemics of obesity, diabetes, and CVD are progressing rapidly. The relevance of this research to public health: The SHS studies diseases of the heart and blood vessels in American Indian Communities, in order to try to explain the rapid increases that have been recently observed. The study is attempting to learn about predictors of disease, and to see to what extent it runs in families. SHS is valuable because it provides information on how diabetes leads to diseases of the heart and blood vessels that will be useful in many populations who now have high rates of diabetes. (End of Abstract)

描述（由申请人提供）： 心血管疾病（CVD）在美国印第安人中流行。强心研究（SHS）通过在3个地理区域（亚利桑那州、达科他州和俄克拉荷马州）的13个社区中进行纵向队列研究和家族遗传研究来检查CVD及其危险因素。本申请提出扩展SHS以追求以下目标：1）扩展遗传研究，其将强调基因组扫描方法，但也包括仔细选择的候选基因的研究。对来自94个大家族的3776个成员进行全基因组扫描，将用于确定数量性状位点，并通过精细定位缩小感兴趣的区域。我们还将研究一些候选基因，这些基因在连锁研究的基础上难以排除，但对血管疾病具有潜在的重要性。2)继续对原始队列（约2859名男性和女性幸存者，年龄60 - 89岁）进行死亡率和发病率监测，并启动对非队列家庭成员的年度死亡率监测和有限的发病率随访。3)重新检查家庭成员，以便分析危险因素的变化，并估计遗传对变化的影响。SHS的优点包括：1）它提供了关于服务不足的族裔群体的健康数据。2)这是美国对糖尿病患者的CVD及其危险因素进行的最大，最长的纵向研究。3)来自心脏、颈动脉和腘动脉超声测量的数据将大大提高对糖尿病血管疾病机制和CVD遗传学的理解。4)这一人群包括一个群体，其中肥胖症和糖尿病的流行在很小的年龄就影响了人们，允许分析遗传和环境对这些疾病的影响，年龄效应的混淆有限。SHS将导致有价值的治疗和预防策略，在美国和世界其他人群中，肥胖，糖尿病和心血管疾病的流行正在迅速发展。这项研究与公共卫生的相关性：SHS研究了美国印第安社区的心脏和血管疾病，以试图解释最近观察到的快速增长。这项研究试图了解疾病的预测因素，并了解它在家庭中的影响程度。SHS是有价值的，因为它提供了关于糖尿病如何导致心脏和血管疾病的信息，这些信息对现在糖尿病发病率高的许多人群都很有用。(End摘要）