BRAIN TUMOR STUDY

脑肿瘤研究

• 批准号: 7420419
• 负责人: HENRY BREM
• 金额: $ 2.09万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420419
• 关键词: brain; diffusion; neoplasm /cancer; orientation; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this project is to assess the usefulness of diffusion tensor imaging (DTI) to diagnose brain tumors. While conventional MRI techniques have been playing crucial roles, there are several important questions that cannot be answered by them. These include information about the boundary of tumor and their properties of growth. For example, it is important to know whether a tumor is growing discretely or infiltrating into neighboring tissues and, if it is infiltrating, what is the orientation of the infiltration. As a preliminary study, the DTI was applied to two patients with astrocytoma. The tumors showed low diffusion anisotropy and high diffusion constant. Compared to conventional T2-weighted images, the images obtained from the DTI are not superior to identify and delineate the boundary of the tumors because the diffusion anisotropy of the tumors is similar to that of normal gray matter. On the other hand, the DTI could reveal detailed anatomy of nearby white matter tracts, which were deformed by growth of the tumor. The results clearly showed that the tumor in one of the patients was growing discretely inducing a large amount of anatomical deformation while the tumor in the other patient did not induce significant white matter deformation, indicating the infiltrating tumor. The orientation of the infiltration coincided with the trajectory of a major association tract, called superior longitudinal fasciculus. This preliminary study suggests that the DTI is a promising technique to precisely delineate deformed neuroanatomy of brain tumor patients. The information is expected to be used for surgical planning to avoid injuring critical white matter tracts and for treatment design by predicting the orientation of the tumor spreading. The result was published in Annals of Neurology (51, 377, 2002).

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本项目的目的是评估弥散张量成像(DTI)在诊断脑肿瘤中的作用。虽然传统的磁共振成像技术一直发挥着至关重要的作用，但有几个重要的问题是它们无法回答的。这些信息包括关于肿瘤边界及其生长特性的信息。例如，重要的是要知道肿瘤是离散生长还是向邻近组织渗透，如果是浸润性的，浸润性的方向是什么。作为初步研究，DTI应用于两名星形细胞瘤患者。肿瘤弥散各向异性低，弥散常数高。与传统的T2加权图像相比，由于肿瘤的扩散各向异性与正常灰质的扩散各向异性相似，DTI获得的图像并不能更好地识别和划定肿瘤的边界。另一方面，DTI可以显示附近白质束的详细解剖，这些白质束因肿瘤的生长而变形。结果显示，其中1例肿瘤呈离散生长，引起大量解剖变形，而另1例肿瘤未引起明显的白质变形，提示为浸润性肿瘤。渗入的方向与称为上纵束的主要联合束的轨迹一致。这项初步研究表明，DTI是一种有前途的技术，可以准确地描绘脑肿瘤患者的畸形神经解剖结构。这些信息有望用于手术计划，以避免损伤关键白质束，并通过预测肿瘤扩散的方向来进行治疗设计。该研究结果发表在《神经学年鉴》(2002年51377期)上。