PREDICTOR@HOME: PROTEIN STRUCTURE PREDICTION VIA THE WORLD-WIDE-WEB
PREDICTOR@HOME:通过万维网预测蛋白质结构
基本信息
- 批准号:7358864
- 负责人:
- 金额:$ 5.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-01 至 2007-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This core research project is directed toward the development, implementation and application of structural bioinformatics methods to protein structure prediction, loop modeling and homology modeling. During the last year we have deployed a new computational infrastructure for protein structure prediction utilizing volunteer computing resources through a world-wide-web distributed computing mechanism. This architecture is based on the BOINC (Berkeley Open Infrastructure for Network Computing) middleware (http://boinc.berkeley.edu) and the software packages CHARMM (biomolecular simulation package) and mfold (lattice-based protein folding code, part of the MMTSB Tool Set) called predictor@home (http://predictor.scripps.edu). Predictor@home is a world-community experiment and effort to use distributed world-wide-web volunteer resources to assemble a supercomputer able to predict protein structure from protein sequence. Our work is aimed at testing and evaluating new algorithms and methods of protein structure prediction in the context of the Sixth Biannual CASP (Critical Assessment of Techniques for Protein Structure Prediction) experiment. The goal is to utilize these approaches together with the immense computer power that can be harnessed through the internet and volunteers all over the world to address critical biomedical questions of protein-related diseases. Our ultimate objective in this project is to deploy these resources to provide a This core research project is directed toward the development, implementation and application of structural bioinformatics methods to protein structure prediction, loop modeling and homology modeling. During the last year we have deployed a new computational infrastructure for protein structure prediction utilizing volunteer computing resources through a world-wide-web distributed computing mechanism. This architecture is based on the BOINC (Berkeley Open Infrastructure for Network Computing) middleware (http://boinc.berkeley.edu) and the software packages CHARMM (biomolecular simulation package) and mfold (lattice-based protein folding code, part of the MMTSB Tool Set) called predictor@home (http://predictor.scripps.edu). Predictor@home is a world-community experiment and effort to use distributed world-wide-web volunteer resources to assemble a supercomputer able to predict protein structure from protein sequence. Our work is aimed at testing and evaluating new algorithms and methods of protein structure prediction in the context of the Sixth Biannual CASP (Critical Assessment of Techniques for Protein Structure Prediction) experiment. The goal is to utilize these approaches together with the immense computer power that can be harnessed through the internet and volunteers all over the world to address critical biomedical questions of protein-related diseases. Our ultimate objective in this project is to deploy these resources to provide a service component structure prediction server for the scientific community.
该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者(PI)可能从另一个NIH来源获得主要资金,因此可以在其他CRISP条目中表示。所列机构为中心,不一定是研究者所在机构。本核心研究计划旨在发展、实施及应用结构生物资讯学方法于蛋白质结构预测、环结构建模及同源性建模。在过去的一年中,我们已经部署了一个新的计算基础设施,通过万维网分布式计算机制,利用志愿者计算资源进行蛋白质结构预测。该架构基于BOINC(Berkeley Open Infrastructure for Network Computing)中间件(http:boinc.berkeley.edu)和称为predictor@home(http://www.example.com)的软件包CHARMM(生物分子模拟包)和mfold(基于晶格的蛋白质折叠代码,MMTSB工具集的一部分)。predictor.scripps.edu Predictor@home是一个全球社区实验,旨在利用分布式万维网志愿者资源组装一台能够从蛋白质序列预测蛋白质结构的超级计算机。我们的工作旨在测试和评估新的算法和方法的蛋白质结构预测的背景下,第六个两年一度的CASP(关键评估技术蛋白质结构预测)实验。我们的目标是利用这些方法,以及通过互联网和世界各地的志愿者可以利用的巨大计算机能力,来解决与蛋白质有关的疾病的关键生物医学问题。我们在这个项目中的最终目标是部署这些资源,以提供一个这个核心研究项目是针对结构生物信息学方法的发展,实施和应用蛋白质结构预测,环建模和同源建模。在过去的一年中,我们已经部署了一个新的计算基础设施,通过万维网分布式计算机制,利用志愿者计算资源进行蛋白质结构预测。该架构基于BOINC(Berkeley Open Infrastructure for Network Computing)中间件(http:boinc.berkeley.edu)和称为predictor@home(http://www.example.com)的软件包CHARMM(生物分子模拟包)和mfold(基于晶格的蛋白质折叠代码,MMTSB工具集的一部分)。predictor.scripps.edu Predictor@home是一个全球社区实验,旨在利用分布式万维网志愿者资源组装一台能够从蛋白质序列预测蛋白质结构的超级计算机。我们的工作旨在测试和评估新的算法和方法的蛋白质结构预测的背景下,第六个两年一度的CASP(关键评估技术蛋白质结构预测)实验。我们的目标是利用这些方法,以及通过互联网和世界各地的志愿者可以利用的巨大计算机能力,来解决与蛋白质有关的疾病的关键生物医学问题。我们在这个项目中的最终目标是部署这些资源,为科学界提供一个服务组件结构预测服务器。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHARLES L BROOKS其他文献
CHARLES L BROOKS的其他文献
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{{ truncateString('CHARLES L BROOKS', 18)}}的其他基金
Theory and Modeling of Biomolecules and their Interactions - Equipment Supplement
生物分子及其相互作用的理论和建模 - 设备补充
- 批准号:
9894101 - 财政年份:2019
- 资助金额:
$ 5.52万 - 项目类别:
Theory and Modeling of Biomolecules and their Interactions
生物分子及其相互作用的理论和建模
- 批准号:
10094219 - 财政年份:2019
- 资助金额:
$ 5.52万 - 项目类别:
Theory and Modeling of Biomolecules and their Interactions - Equipment Supplement
生物分子及其相互作用的理论和建模 - 设备补充
- 批准号:
10580491 - 财政年份:2019
- 资助金额:
$ 5.52万 - 项目类别:
Theory and Modeling of Biomolecules and their Interactions
生物分子及其相互作用的理论和建模
- 批准号:
10554419 - 财政年份:2019
- 资助金额:
$ 5.52万 - 项目类别:
Theory and Modeling of Biomolecules and their Interactions
生物分子及其相互作用的理论和建模
- 批准号:
10333335 - 财政年份:2019
- 资助金额:
$ 5.52万 - 项目类别:
Acid-mediated processes in nucleic acids and proteins
核酸和蛋白质中酸介导的过程
- 批准号:
8854117 - 财政年份:2014
- 资助金额:
$ 5.52万 - 项目类别:
Acid-mediated processes in nucleic acids and proteins
核酸和蛋白质中酸介导的过程
- 批准号:
8691310 - 财政年份:2014
- 资助金额:
$ 5.52万 - 项目类别:
Acid-mediated processes in nucleic acids and proteins
核酸和蛋白质中酸介导的过程
- 批准号:
9068970 - 财政年份:2014
- 资助金额:
$ 5.52万 - 项目类别:
Acid-mediated processes in nucleic acids and proteins
核酸和蛋白质中酸介导的过程
- 批准号:
9294086 - 财政年份:2014
- 资助金额:
$ 5.52万 - 项目类别:
CORE 2006-2011: COMPUTATIONAL IMPLEMENTATION OF A TIME CORRELATION FUNCTION THE
CORE 2006-2011:时间相关函数的计算实现
- 批准号:
8364273 - 财政年份:2011
- 资助金额:
$ 5.52万 - 项目类别:
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