SIGNALING AND ACTIN NUCELATION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。NCK分子已成为受体激活的细胞骨架重组的重要调节因子。特别是，含有NNCK结合域的受体复合体的聚集在聚集的位置产生肌动蛋白聚合的彗星尾巴。我们将使用虚拟信元对该系统进行建模，以努力剖析该行为背后的复杂信令网络

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Nck molecule has emerged as an important regulator of receptor activated cytoskeletal reorganization. In particular, aggregation of a receptor complex containing a nNck binding domain produces comet tails of actin polymerization at the site of aggregation. We will model this system with the Virtual Cell in an effort to dissect th complex signaling network underlying this behavior