SIGNALING AND ACTIN NUCELATION

信号传导和肌动蛋白成核

• 批准号: 7956392
• 负责人: BRUCE J. MAYER
• 金额: $ 6.51万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956392
• 关键词: Actins; Behavior; Binding; Biological Models; Cells; Complex; Computer Retrieval of Information on Scientific Projects Database; Cytoskeletal Modeling; Funding; Grant; Institution; Modeling; Research; Research Personnel; Resources; Signal Transduction; Site; Source; Tail; United States National Institutes of Health; polymerization; receptor; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Nck molecule has emerged as an important regulator of receptor activated cytoskeletal reorganization. In particular, aggregation of a receptor complex containing a nNck binding domain produces comet tails of actin polymerization at the site of aggregation. We will model this system with the Virtual Cell in an effort to dissect the complex signaling network underlying this behavior

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