VISUAL CORTEX & RECONSTRUCTIONS & REPRESENTATIONS OF CEREBRAL CORTEX

视觉皮层

• 批准号: 7420424
• 负责人: DAVID C VAN ESSEN
• 金额: $ 2.09万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420424
• 关键词: Primates; cerebral cortex; human; visual cortex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Neuroscientists have obtained vast amounts of experimental data about the organization and function of the cerebral cortex in humans and in non-human primates, especially the macaque monkey. To cope with this flood of information, new tools and strategies are necessary in order to adequately analyze and communicate these findings. The objective of our brain-mapping research in collaboration with TRD4 is to develop improved methods for visualizing, analyzing, and communicating information about the cerebral cortex, and to apply these methods to a variety of experimental data sets in humans and nonhuman primates. A central focus of TRD4 involves the development of explicit surface reconstructions to represent the shape of the cortical sheet. The need for cortical surface reconstructions arises from the complex pattern of convolutions of the cerebral cortex, particularly in humans, and from the high degree of individual variability in the pattern of folds. Cortical con volutions and their variability have long been matters of both frustration and fascination to neuroscientists. The frustration arises because the convolutions make it difficult to visualize important spatial relationships and to specify locations on the cortical surface with precision and confidence. The fascination arises because of curiosity about how the convolutions arise during development and what they signify functionally. The major goals of our projects are generating fundus curves on cortical membranes, the anatomical features of deepest curvature of cortical surfaces (TRD4-Aim 3). These provide the landmarks for the development of the new mapping algorithms (TRD4-Aims 2, 5) enabling important functional differences between individuals or across groups with different diagnostic categories to be correlated with differences in cortical structure and the pattern of convolutions. Progress: Spherical diffomeorphic mapping for landmarks have been implemented and debugged. Several brains from Dr. Van Essen's laboratory have now been analyzed, generating the diffeomorphisms corresponding to matching the sulcul boundaries as defined by Dr. Van Essen.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。神经科学家已经获得了大量关于人类和非人类灵长类动物（特别是猕猴）大脑皮层组织和功能的实验数据。为了科普这一信息洪流，需要新的工具和战略，以便充分分析和交流这些调查结果。我们与TRD 4合作进行的脑映射研究的目的是开发改进的方法，用于可视化，分析和交流有关大脑皮层的信息，并将这些方法应用于人类和非人类灵长类动物的各种实验数据集。TRD 4的一个中心焦点涉及发展明确的表面重建，以代表皮质片的形状。对皮质表面重建的需要来自于大脑皮质的复杂的卷积模式，特别是在人类中，以及来自于褶皱模式的高度个体变异性。长期以来，大脑皮层的卷积及其变异性一直是神经科学家们既沮丧又着迷的问题。之所以会出现这种挫折，是因为卷积使人们难以将重要的空间关系可视化，也难以精确而自信地指定皮层表面的位置。之所以如此着迷，是因为人们对卷积在开发过程中是如何出现的以及它们在功能上意味着什么感到好奇。我们项目的主要目标是在皮质膜上生成眼底曲线，这是皮质表面最深曲率的解剖学特征（TRD 4-Aim 3）。这些为开发新的映射算法（TRD 4-目标2，5）提供了里程碑，使具有不同诊断类别的个体或群体之间的重要功能差异与皮质结构和卷积模式的差异相关。进展：已实施和调试标志的球形扩散变形标测。货车·埃森实验室的几个大脑现在已经被分析，产生了与货车·埃森博士定义的脑沟边界相匹配的脑沟形态。