MULTISCALE MODELS FOR PACKAGING VIRAL DNAS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们正在继续我们的双链DNA包装成病毒衣壳的调查，特别强调噬菌体。该研究使用了一种简化的表示模型，即每10个碱基对有一个假原子（原始模型），或每6个碱基对有一个假原子（修正模型）。目标是了解DNA包装成病毒的结构、动力学和热力学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are continuing our investigation of the packaging of double-stranded DNA into viral capsids, with particular emphasis on bacteriophage. The studies use a reduced representation model with one pseudoatom for every ten basepairs (original model), or one pseudoatom for every six basepairs (revised model). The goal is to understand the structural, kinetic, and thermodynamics of DNA packaging into viruses.