MULTISCALE MODELS FOR PACKAGING VIRAL DNAS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are continuing our investigation of the packaging of double-stranded DNA into viral capsids, with particular emphasis on bacteriophage. The studies use a reduced representation model with one pseudoatom for every ten basepairs (original model), or one pseudoatom for every six basepairs (revised model). The goal is to understand the structural, kinetic, and thermodynamics of DNA packaging into viruses.