INTERGENERATIONAL TRANSMISSION OF ANTISOCIAL BEHAVIOR

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。众所周知，反社会行为会在家庭中遗传，但令人惊讶的是，人们对其代代相传的具体机制知之甚少。虽然代际传递范式在解决这一问题方面越来越有影响力，但很少有这样的研究是前瞻性的，包括父母双方，关注早期机制，并解决女性和男性的反社会行为。重要的是，迄今为止还没有人研究过生物对跨代连续性和变化的影响，或者它们如何与调节反社会行为传播的社会因素相互作用。提出的三代研究试图通过利用一种新颖的设计来解决这些知识上的差距，在这种设计中，1,795名男性和女性在3岁时接受心理生理、行为、营养和认知方面的测试，而他们的第一代父母则接受心理社会影响的评估。这些第二代三岁儿童现在已年满30岁，将与他们的第三代三岁子女一起重新接受心理生理、社会心理、认知、行为、养育子女和反社会行为方面的测试。第二代父母和他们之前未接受测试的配偶都将接受心理生理测试，以及生活压力、日常争吵、家庭冲突、精神疾病和犯罪行为的测试。该研究还将评估100名第二代受试者在3-5岁期间的营养、运动和教育丰富，是否会破坏第二代到第三代的反社会行为的代际传递。这些营养、运动和教育丰富会导致11岁时的生理觉醒和注意力增加，17岁时的行为障碍减少。人们认为，这项研究提供了一个真正独特的机会来理解未被探索的问题，即生物影响如何与社会环境相互作用，阻碍或促进反社会和攻击行为的代际传播。这一新知识如果得到进一步发展，将有助于制定新一代更有效的预防方案，以减少反社会和暴力行为。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While it is well-known that antisocial behavior runs in families, surprisingly little is known about the specific mechanisms by which it is transmitted from one generation to the next. While the intergenerational transmission paradigm is becoming increasingly influential in addressing this issue, very few such studies are prospective, include both parents, focus on early mechanisms, and address female as well as male antisocial behavior. Importantly, none to date have examined biological influences on transgenerational continuity and change, or how they interact with social factors in modulating the transmission of antisocial behavior. The proposed three-generation study attempts to address these gaps in knowledge by capitalizing on a novel design in which I ,795 males and females were tested on psychophysiological, behavioral, nutritional, and cognitive measures at age 3, while their first-generation parents were assessed on psychosocial influences. These second-generation three-year-olds are now aged 30 years and will be retested, together with their third-generation three-year-old offspring, on psychophysiological, psychosocial, cognitive, behavioral, parenting, and antisocial behavior measures. Both the second generation parent and their previously untested spouse will be tested on psychophysiological measures, together with measures of life stress, daily hassles, family conflict, mental illness, and criminal behavior. The study will also assess whether a nutritional, exercise, and educational enrichment from ages 3-5 years in 100 of the second generation subjects, which has lead to increased physiological arousal and attention at age 11 years and reduced conduct disorder at age 17 years, disrupts the intergenerational transmission of antisocial behavior from the second to third generations. It is thought that the study offers a truly unique opportunity to understand the unexplored issue of how biological influences interact with social contexts in either blocki ng or facilitating the intergenerational transmission of antisocial and aggressive behavior. This new knowledge, if further developed, could contribute to a new generation of more effective prevention programs for reducing antisocial and violent behavior.