INTERGENERATIONAL TRANSMISSION OF ANTISOCIAL BEHAVIOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然众所周知，反社会行为在家庭中存在，但令人惊讶的是，人们对这种行为如何从一代传到下一代的具体机制知之甚少。虽然代际传播范式在解决这一问题上正变得越来越有影响力，但很少有这样的研究是前瞻性的，包括父母双方，关注早期机制，并解决女性和男性的反社会行为。重要的是，到目前为止，还没有人研究过对代际延续和变化的生物学影响，或者它们如何与调节反社会行为传播的社会因素相互作用。这项拟议的三代研究试图通过利用一项新颖的设计来解决这些知识差距。在这项设计中，我对795名男性和女性在3岁时进行了心理生理、行为、营养和认知方面的测试，而他们的第一代父母则接受了心理社会影响的评估。这些第二代三岁的孩子现在30岁，将与他们的第三代三岁的后代一起接受心理生理、心理社会、认知、行为、育儿和反社会行为测量的重新测试。第二代父母和他们以前没有测试过的配偶都将接受心理生理测量，以及生活压力、日常麻烦、家庭冲突、精神疾病和犯罪行为的测量。这项研究还将评估100名第二代受试者从3-5岁开始的营养、锻炼和教育丰富，这导致了11岁时生理唤醒和注意力的增加，以及17岁时行为障碍的减少，是否扰乱了反社会行为从第二代到第三代的代际传播。人们认为，这项研究提供了一个真正独特的机会来理解尚未探索的问题，即生物影响如何与社会背景相互作用，无论是阻碍还是促进反社会和攻击性行为的代际传播。这一新知识，如果进一步发展，可能有助于新一代更有效的预防计划，以减少反社会和暴力行为。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While it is well-known that antisocial behavior runs in families, surprisingly little is known about the specific mechanisms by which it is transmitted from one generation to the next. While the intergenerational transmission paradigm is becoming increasingly influential in addressing this issue, very few such studies are prospective, include both parents, focus on early mechanisms, and address female as well as male antisocial behavior. Importantly, none to date have examined biological influences on transgenerational continuity and change, or how they interact with social factors in modulating the transmission of antisocial behavior. The proposed three-generation study attempts to address these gaps in knowledge by capitalizing on a novel design in which I ,795 males and females were tested on psychophysiological, behavioral, nutritional, and cognitive measures at age 3, while their first-generation parents were assessed on psychosocial influences. These second-generation three-year-olds are now aged 30 years and will be retested, together with their third-generation three-year-old offspring, on psychophysiological, psychosocial, cognitive, behavioral, parenting, and antisocial behavior measures. Both the second generation parent and their previously untested spouse will be tested on psychophysiological measures, together with measures of life stress, daily hassles, family conflict, mental illness, and criminal behavior. The study will also assess whether a nutritional, exercise, and educational enrichment from ages 3-5 years in 100 of the second generation subjects, which has lead to increased physiological arousal and attention at age 11 years and reduced conduct disorder at age 17 years, disrupts the intergenerational transmission of antisocial behavior from the second to third generations. It is thought that the study offers a truly unique opportunity to understand the unexplored issue of how biological influences interact with social contexts in either blocki ng or facilitating the intergenerational transmission of antisocial and aggressive behavior. This new knowledge, if further developed, could contribute to a new generation of more effective prevention programs for reducing antisocial and violent behavior.