Intergenerational Transmission of Antisocial Behavior

反社会行为的代际传播

• 批准号: 7633642
• 负责人: ADRIAN RAINE
• 金额: $ 16.89万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-18 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7633642
• 关键词: academic achievement; adolescence (12-20); aggression; antisocial personality; arousal; attention; behavioral /social science research tag; child (0-11); child psychology; clinical research; cognition; exercise; generation difference; human subject; longitudinal human study; nutrition; parent offspring interaction; psychological tests; social behavior disorders; social psychology; young adult human (21-34)

DESCRIPTION (provided by applicant): While it is well-known that antisocial behavior runs in families, surprisingly little is known about the specific mechanisms by which it is transmitted from one generation to the next. While the intergenerational transmission paradigm is becoming increasingly influential in addressing this issue, very few such studies are prospective, include both parents, focus on early mechanisms, and address female as well as male antisocial behavior. Importantly, none to date have examined biological influences on transgenerational continuity and change, or how they interact with social factors in modulating the transmission of antisocial behavior. The proposed three-generation study attempts to address these gaps in knowledge by capitalizing on a novel design in which I ,795 males and females were tested on psychophysiological, behavioral, nutritional, and cognitive measures at age 3, while their first-generation parents were assessed on psychosocial influences. These second-generation three-year-olds are now aged 30 years and will be retested, together with their third-generation three-year-old offspring, on psychophysiological, psychosocial, cognitive, behavioral, parenting, and antisocial behavior measures. Both the second generation parent and their previously untested spouse will be tested on psychophysiological measures, together with measures of life stress, daily hassles, family conflict, mental illness, and criminal behavior. The study will also assess whether a nutritional, exercise, and educational enrichment from ages 3-5 years in 100 of the second generation subjects, which has lead to increased physiological arousal and attention at age 11 years and reduced conduct disorder at age 17 years, disrupts the intergenerational transmission of antisocial behavior from the second to third generations. It is thought that the study offers a truly unique opportunity to understand the unexplored issue of how biological influences interact with social contexts in either blocking or facilitating the intergenerational transmission of antisocial and aggressive behavior. This new knowledge, if further developed, could contribute to a new generation of more effective prevention programs for reducing antisocial and violent behavior.

描述（由申请人提供）：虽然众所周知，反社会 行为在家庭中运行，令人惊讶的是，对具体的 通过这种机制，它从一代传递到下一代。而 代际传递模式越来越多地 在解决这个问题的影响，很少有这样的研究是前瞻性的， 包括父母双方，注重早期机制，并处理妇女以及 男性反社会行为重要的是，迄今为止还没有人检查过生物学 对跨代连续性和变化的影响，或它们如何互动 与社会因素在调节反社会行为的传播。 拟议的三代研究试图解决这些知识差距 通过利用一个新颖的设计，1795名男性和女性被测试， 心理生理，行为，营养和认知措施的年龄 3，而他们的第一代父母进行了社会心理评估， 影响。这些第二代三岁的孩子现在已经30岁了， 将和他们的第三代三岁大的孩子一起接受重新测试 后代，对心理生理，社会心理，认知，行为， 父母教养和反社会行为测试第二代父母 而他们之前未接受过测试的配偶将接受心理生理测试， 措施，以及生活压力、日常麻烦、家庭 冲突、精神疾病和犯罪行为。该研究还将评估 是否从3 - 5岁开始进行营养、锻炼和教育强化 在100名第二代受试者中， 11岁时的生理唤醒和注意力以及行为减少 17岁时的疾病，破坏了 从第二代到第三代的反社会行为 人们认为，这项研究提供了一个真正独特的机会， 生物影响如何与社会环境相互作用的未探索问题 在阻止或促进疾病的代际传播方面， 反社会和攻击性行为这些新知识，如果进一步发展， 可以为新一代更有效的预防计划做出贡献， 减少反社会和暴力行为。

项目成果

Abnormal structural correlates of response perseveration in individuals with psychopathy.

精神病患者反应持续的异常结构相关性。

• DOI: 10.1176/jnp.23.1.jnp107
• 发表时间: 2011
• 期刊: The Journal of neuropsychiatry and clinical neurosciences
• 作者: Yang,Yaling;Raine,Adrian;Colletti,Patrick;Toga,ArthurW;Narr,KatherineL
• 通讯作者: Narr,KatherineL

Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: a meta-analysis.

• DOI: 10.1016/j.pscychresns.2009.03.012
• 发表时间: 2009-11-30
• 期刊: PSYCHIATRY RESEARCH-NEUROIMAGING
• 影响因子: 2.3
• 作者: Yang, Yaling;Raine, Adrian
• 通讯作者: Raine, Adrian

Morphological alterations in the prefrontal cortex and the amygdala in unsuccessful psychopaths.

• DOI: 10.1037/a0019611
• 发表时间: 2010-08
• 期刊: Journal of abnormal psychology
• 影响因子: 4.6
• 作者: Yaling Yang;A. Raine;P. Colletti;A. Toga;K. Narr

Reduced hippocampal and parahippocampal volumes in murderers with schizophrenia.

• DOI: 10.1016/j.pscychresns.2009.10.013
• 发表时间: 2010-04-30
• 期刊: PSYCHIATRY RESEARCH-NEUROIMAGING
• 影响因子: 2.3
• 作者: Yang, Yaling;Raine, Adrian;Han, Chen-Bo;Schug, Robert A.;Toga, Arthur W.;Narr, Katherine L.
• 通讯作者: Narr, Katherine L.