MRI ASSESSMENT OF PALLIDOTOMY LESION PLACEMENT AND POST-OPERATIVE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。近年来，使用射频腹后侧苍白球切开术（VPP）作为帕金森病（PD）医学难治性运动症状的对症治疗已得到广泛接受。一些研究中心报告了在控制特发性PD患者的致残性运动障碍、开/关波动和其他运动症状方面的显著改善（Baron等，1996；Dogali等，1995；Iacono等，1995；Johansson等，1997；Lang等，1997；Laitinen等，1992a； Laitinen等，1992b； Lozano等，1995；Uitti等，1997）。尽管普遍认为VPP对许多患者都有帮助，但患者和实施手术的中心之间的结果差异很大。这种差异的一个原因可能是由于病变位置和大小的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recent years, the use of radiofrequency ventroposterior pallidotomy (VPP) as a symptomatic treatment for the medically refractory motor symptoms of Parkinson¿s disease (PD) has been gaining widespread acceptance. A number of centers have reported significant improvements in controlling disabling dyskinesias, on/off fluctuations and other motor symptoms in patients with idiopathic PD (Baron et al., 1996; Dogali et al., 1995; Iacono et al., 1995; Johansson et al., 1997; Lang et al., 1997; Laitinen et al., 1992a; Laitinen et al., 1992b; Lozano et al., 1995; Uitti et al., 1997). Although there is a general agreement that VPP is helpful for many patients, results vary considerably between patients and centers performing the operation. One reason for this variability is likely due to differences in lesion placement and size.