MRI PALLIDOTOMY LESION PLACEMENT & POST OPERATIVE LOCALIZATION IN PARKINSONS DIS

可视化生物医学数据通常是其 认识 如果我们能看到一个结构，我们就能识别它。 可视化使我们能够从 复杂的数据集。 虽然研究大脑的所有 复杂性要求一种简化的科学方法。 其 多维组合适合于各种计算机化的 与重建有关的可视化技术。 表示. 操纵和显示。 通过采用 图像处理技术。 图像合成与计算机 我们联合收割机结合了图像和数字的效用，使我们能够 统计学上衡量视觉表现。 结构 随着时间的推移，变化可能会进一步复杂化我们的能力， 理解特定的几何形状或属性之间的关系。 添加动画可视化的功能不仅可以帮助我们 理解多维模型，但将促进其 沟通也是。 具体目标。 我们在这个研究项目中的总体目标是 开发包含空间的多维成像工具。 时间 并以统计学上有意义的方式对数据进行属性化。 我们将开发 增强我们现有的软件工具套件， 互动 具有真实的时间反馈的数据控制和显示， 除了改进大型数据集的非交互式处理之外 或更复杂的渲染。 我们将容纳两个数量和 表面为基础的方法和开发模块的'插件' 内部和其他公司开发的其他软件的能力 组 我们计划借鉴成功和成熟的方法， 可能的话，设计和鼓励软件合作， 开发人员，主要专注于我们自己的利基，这是可视化 多维数据和动画。 我们的具体目标是 具体目标1。 创建一个动画制作软件系统 来传达复杂的信息。 动态变化结构 和结构/功能关系。 具体目标2。 构建可视化/动画包的子集 实现与多维模型的实时交互， 改进数据的探索，并开发一个接口， 可视化/动画插件可以插入到软件中 执行研究中描述的分析和建模的程序 项目一至三。 插件将使调查员能够 将这些计算的中间产物可视化为程序 正在运行。 这使得能够更严格地控制 具体参数和计算密集型程序的操作。 具体目标3。 写作，渲染。 动画制作短片 介绍神经科学中的交流概念。 这些将 最初示出了诸如视觉系统的感觉系统， 最终被用来交流科学选择 合作项目。 它们将联合收割机合成产生的 具有真实的数据的图像，以最好地传达概念。 具体目标4。 开发成熟的可视化/动画软件， 可以用VRML或Java实现，将解决方案迁移到这些WEB 只要有可能，系统。

Visualizing biomedical data is often a prerequisite to its understanding. If we can visualize a structure, we can identify it. Visualization enables us to extract meaningful information from complex data sets. Although researching the brain in all its complexity mandates a reductionistic scientific approach. its multidimensional composition lends itself to a variety of computerized visualization techniques concerned with reconstruction. representation. manipulation and display. By employing the techniques of image processing. image synthesis and computer graphics, we combine the utility of image and number enabling us to statistically measure the visual representation. Structures that change over time can further complicate our ability to fully comprehend a particular geometry or relationships between attributes. Adding the ability to animate the visualization will help us not only to understand a multidimensional model but will facilitate its communication as well. Specific Aims. Our overall goal in this research project is to develop multidimensional imaging tools that incorporate space. time and attribute data in a statistically meaningful way. We will develop enhancements to our existing suite of software tools for the interaction. control and display of data with real time feedback in addition to improving noninteractive processing for larger data sets or more complex renderings. We will accommodate both volume and surface based methods and develop the modules for 'plug in' capabilities with other software developed in house and by other groups. We plan to borrow approaches that are successful and mature when possible, design and encourage software cooperation among other developers and focus primarily on our own niche which is visualization of multidimensional data and animation. Our specific aims are Specific Aim 1. Create an animation software system for the creation of visualizations to convey complex. dynamically changing structure and structure/function relationships. Specific Aim 2. Build a subset of the visualization/animation package that enables real-time interaction with multidimensional models for improved exploration of the data and develop an interface so that visualization/animation plug-ins can, be inserted into software programs performing the analyses and modeling described in research projects I-III. The plug-ins will enable the investigator to visualize the interim product of these calculations as the programs are running. This enable tighter control over the selection of specific parameters and the operation of compute intensive procedures. Specific Aim 3. Write, render. animate and produce short video presentations for communicating concepts in neuroscience. These will initially illustrate sensory systems such as the visual system and ultimately be used to communicate the science of selected collaborative projects. They will combine synthetically generated images with real data to best communicate the concept. Specific Aim 4. Develop mature visualization/animation software that can be implemented with VRML or Java, migrating solutions to these WEB based systems whenever possible.