STRUCTURAL GENOMICS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。BNL的生物部是NYSGXRC的成员之一，该中心由美国国立卫生研究院根据他们的蛋白质结构倡议(PSI)计划资助。PSI的目标是使用实验和结构建模技术的组合来提供几乎所有自然产生的蛋白质序列的结构信息。NYSGXRC使用X射线结晶学进行结构确定，并使用模型器对同一家族的同源蛋白质进行建模。NYSGXRC的许多靶标选择策略都是基于生物学的，以某种方式提供了一组与更大的蛋白质相关并代表更大蛋白质的蛋白质。这些策略包括：酶途径的所有成员，大分子复合体中的每个蛋白质，通过双杂交筛选或生物信息学分析确定的相关蛋白质的相互作用伙伴，或通过DNA微阵列技术确定的在生物过程中上调和下调的一组基因产物，或一组功能和结构未知但对流感嗜血杆菌生存重要的蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biology Department of BNL is a member of the NYSGXRC funded by the National Institutes of Health under their Protein Structure Initiative (PSI) program. The goal of the PSI is to provide structural information for virtually all naturally occurring protein sequences using a combination of experimental and structure modeling techniques. The NYSGXRC uses X-ray crystallography for structure determination and MODELER for modeling homologous proteins of the same family. Many of the target selection strategies of the NYSGXRC are biologically based, providing a set of proteins that are related and representative of a larger set of proteins in some fashion. The strategies include: all members of an enzymatic pathway, each protein in macromolecular complex, interacting partners of related proteins identified using 2-hybrid screening or bioinformatics analysis, or a group of gene products up and down-regulated in a biological process as determined by DNA-microarray techniques, or a group of proteins of unknown function and structure but known to be important for the survival of H. influenzae.