STRUCTURAL GENOMICS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。BNL生物系是由美国国立卫生研究院在其蛋白质结构倡议（PSI）计划下资助的NYSGXRC的成员。PSI的目标是使用实验和结构建模技术的组合来提供几乎所有天然存在的蛋白质序列的结构信息。NYSGXRC使用X射线晶体学进行结构测定，并使用MODELER对同一家族的同源蛋白质进行建模。NYSGXRC的许多靶选择策略是基于生物学的，提供了一组相关的蛋白质，并以某种方式代表了一组更大的蛋白质。这些战略包括：酶途径的所有成员，大分子复合物中的每种蛋白质，使用双杂交筛选或生物信息学分析鉴定的相关蛋白质的相互作用伴侣，或通过DNA微阵列技术确定的在生物过程中上调和下调的一组基因产物，或功能和结构未知但已知对H.流感。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biology Department of BNL is a member of the NYSGXRC funded by the National Institutes of Health under their Protein Structure Initiative (PSI) program. The goal of the PSI is to provide structural information for virtually all naturally occurring protein sequences using a combination of experimental and structure modeling techniques. The NYSGXRC uses X-ray crystallography for structure determination and MODELER for modeling homologous proteins of the same family. Many of the target selection strategies of the NYSGXRC are biologically based, providing a set of proteins that are related and representative of a larger set of proteins in some fashion. The strategies include: all members of an enzymatic pathway, each protein in macromolecular complex, interacting partners of related proteins identified using 2-hybrid screening or bioinformatics analysis, or a group of gene products up and down-regulated in a biological process as determined by DNA-microarray techniques, or a group of proteins of unknown function and structure but known to be important for the survival of H. influenzae.