STRUCTURAL GENOMICS CENTERS FOR INFECTIOUS DISEASES

传染病结构基因组中心

• 批准号: 10441028
• 负责人: PETER MYLER
• 金额: $ 44.89万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441028
• 关键词: 3-Dimensional; Antimicrobial Resistance; Basic Science; Biological; Biomedical Research; Categories; Emerging Communicable Diseases; Genomic Centers for Infectious Diseases; Goals; Gram-Positive Bacteria; Molecular; National Institute of Allergy and Infectious Disease; Organism; Proteins; Research Project Grants; Research Support; Role; Structure; Technology; pathogen; priority pathogen; programs; structural biology; structural genomics; three dimensional structure

The goal of the Structural Genomics Centers for Infectious Diseases is to apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms causing emerging and re-emerging infectious diseases. This program also supports research projects that utilize the 3D structure information and experimental approaches to better characterize the molecular functional role of protein targets. The primary focus of the Center is pathogen proteins that are expected to have an important biological role and a potential impact on biomedical research.

传染病结构基因组学中心的目标是应用最先进的高通量结构生物学技术，以实验方式表征NIAID A-C类优先病原体列表上的靶蛋白质的三维原子结构，以及引起新发和复发传染病的生物体。该计划还支持利用3D结构信息和实验方法更好地表征蛋白质靶点的分子功能作用的研究项目。该中心的主要重点是病原体蛋白，预计将有一个重要的生物学作用和生物医学研究的潜在影响。