STRUCTURAL GENOMICS

结构基因组学

• 批准号: 8170594
• 负责人: SUBRAMANYAM SWAMINATHAN
• 金额: $ 1.02万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170594
• 关键词: Amino Acid Sequence; Bioinformatics; Biological Process; Biology; Computer Retrieval of Information on Scientific Projects Database; Crystallography; DNA Microarray Chip; Family; Funding; Goals; Grant; Haemophilus influenzae; Homologous Protein; Hybrids; Institution; Macromolecular Complexes; Modeling; Pathway interactions; Peptide Sequence Determination; Protein Structure Initiative; Proteins; Research; Research Personnel; Resources; Screening procedure; Set protein; Source; Structure; Techniques; United States National Institutes of Health; X-Ray Crystallography; base; member; programs; structural genomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biology Department of BNL is a member of the NYSGXRC funded by the National Institutes of Health under their Protein Structure Initiative (PSI) program. The goal of the PSI is to provide structural information for virtually all naturally occurring protein sequences using a combination of experimental and structure modeling techniques. The NYSGXRC uses X-ray crystallography for structure determination and MODELER for modeling homologous proteins of the same family. Many of the target selection strategies of the NYSGXRC are biologically based, providing a set of proteins that are related and representative of a larger set of proteins in some fashion. The strategies include: all members of an enzymatic pathway, each protein in macromolecular complex, interacting partners of related proteins identified using 2-hybrid screening or bioinformatics analysis, or a group of gene products up and down-regulated in a biological process as determined by DNA-microarray techniques, or a group of proteins of unknown function and structure but known to be important for the survival of H. influenzae.

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