Contingent Tolerance to Cocaine in Pigeons

描述（由申请人提供）：先前对大鼠和猴子对可卡因的耐受性影响的研究表明，耐受性取决于药物是在服用前还是服用后。最近发表的一项对鸽子的实验和初步研究并没有发现耐受性同样取决于给药的时间。本研究将通过三个实验进一步探讨行为因素和药理因素在鸽子可卡因耐受发展中的作用。实验1将检验在可卡因作用下进食对前一操作行为阶段可卡因耐受性发展的贡献。实验2将检验仅接触毒品而不接触行为环节对行为环节期间可卡因耐受性发展的影响。实验3将检验急性和慢性可卡因给药对可卡因药代动力学的影响。这个研究项目将研究行为因素的作用，包括实验过程和饮食，以及药理学因素在鸽子对可卡因行为影响的耐受性发展中的作用。

DESCRIPTION (provided by applicant): Previous research on tolerance to effects of cocaine on operant behavior in rats and monkeys has revealed tolerance contingent on whether the drug is given pre or post session. A recently published experiment with pigeons, and the preliminary study did not find that tolerance was similarly contingent on when the drug was administered. The proposed research will further examine the role of behavioral factors and pharmacological factors in the development of tolerance to cocaine in pigeons through three experiments. Experiment 1 will examine the contributions of eating while under the effects of cocaine to the development of tolerance to cocaine during a preceding operant behavioral session. Experiment 2 will examine effects of mere drug exposure without exposure to a behavioral session in the development of tolerance to cocaine during a behavioral session. Experiment 3 will examine effects of acute and chronic cocaine administration on the pharmacokinetics of cocaine. This program of research will examine the role of behavioral factors, including the experimental session and eating, and pharmacological factors in the development of tolerance to behavioral effects of cocaine in pigeons.