Thiolactones in carbohydrate chemistry

碳水化合物化学中的硫代内酯

• 批准号: EP/D051495/1
• 负责人: Stuart Conway
• 金额: $ 15.39万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD051495%2F1
• 关键词: Thiolactones; carbohydrate; chemistry

This research project centers around investigations of some fundamental, but as yet not studied, reactions of carbohydrate thiolactones. The project can be broken down into the following areas:1) The development of new and improved synthetic methods to carbohydrate thiolactones that will allow their facile synthesis on a multi gram scale, making them viable synthetic intermediates and amenable for further study2) Study and optimization of the reactivity of these thiolactones with a variety of alcohols, under different types of reaction conditions3) Investigation of the use of thiolactones for the total synthesis of a class of highly potent anti-fungal compounds called the Papulacandins. Analogs will also be synthesized and their biological activity tested by our collaborators.4) Investigation of some novel reduction reactions of compounds derived in section 2) above, in an attempt to open up a new way for controlling the stereochemistry of glycosylation reactions.

本研究项目围绕着一些基本的，但尚未研究，碳水化合物硫代内酯的反应的调查。该项目可以分为以下几个方面：1）开发新的和改进的合成方法，以碳水化合物硫代内酯，这将使其易于在多克规模上合成，使其成为可行的合成中间体，并适合进一步研究2）研究和优化这些硫代内酯与各种醇的反应性，在不同类型的反应条件下3）研究硫代内酯用于一类称为Papulacandins的高效抗真菌化合物的全合成。4）研究了2）中衍生化合物的一些新的还原反应，试图为糖基化反应的立体化学控制开辟一条新的途径。