Research Training-Clinical Neurosciences-Stress Disorders

描述（由申请人提供）：该培训计划的主要目的是增加训练有素的研究人员的数量，这些研究人员进行与极端压力和创伤相关疾病（例如创伤后应激障碍）相关的神经科学研究。在过去的十年中，在理解压力的生理学、生物化学、神经回路、药理学和行为表现方面取得了非凡的临床前进展。这些进展现在使得检验有关人类应激相关疾病的病理生理学和治疗的合理假设成为可能。然而，目前致力于将这些临床前发现转化为与压力相关的人类神经生物学研究的基础和临床神经科学家相对较少。为了满足这一迫切需求，我们提议为博士后研究员（高级精神病学住院医师、精神病学家和在神经科学、神经生物学、药理学和心理学等创伤相关研究相关学科完成博士学位的博士）提供培训补助金，以寻求在极端压力和创伤相关疾病的神经生物学方面获得深入的研究培训。耶鲁大学精神病学系与国家创伤后应激障碍中心临床神经科学部门和耶鲁大学儿童研究中心合作，将为这项培训拨款提供环境。该奖学金将持续两年，并可以选择继续第三年。每年都会选出两名新研究员参加该计划。研究员将与项目导师和单独的研究导师密切合作。这些导师将监督该研究员的所有研究和培训活动。 该奖学金包括核心课程，学员将培养与研究设计和方法、统计学、研究道德行为、心理和行为评估以及创伤相关神经科学基础知识相关的技能。此外，研究员还将选修与其感兴趣的特定研究领域相关的选修课程。学员将通过加入研究导师正在进行的项目来开始实践研究活动。然后，在研究导师的帮助下，他们将设计并开展自己的创伤相关研究项目。 精神病学系、国家创伤后应激障碍中心临床神经科学部门和耶鲁儿童研究中心在培养基础和临床神经科学方面的全国杰出研究人员方面都有着出色的记录。当前的申请旨在通过培训与极端应激障碍相关的神经科学研究的博士后研究员，为 NIMH 的研究目标做出贡献。

DESCRIPTION (provided by applicant): The primary purpose of this training program is to increase the number of fully trained investigators who conduct neuroscience research related to extreme stress and trauma-related disorders, such as posttraumatic stress disorder. Over the past decade exceptional pre-clinical advances have been made in understanding the physiology, biochemistry, neural circuitry, pharmacology and behavioral manifestations of stress. These advances have now made it possible to test rational hypotheses regarding the pathophysiology and treatment of stress-related disorders in humans. However, currently there are relatively few basic and clinical neuroscientists who devote their career to translating these pre-clinical findings into relevant stress-related human neurobiological research. To address this pressing need, we propose a training grant for postdoctoral fellows (advanced psychiatry residents, psychiatrists, and PhDs who have completed their doctorate in disciplines relevant to trauma-related research such as neuroscience, neurobiology, pharmacology and psychology) who seek to gain in-depth research training in the neurobiology of extreme stress and trauma-related disorders. The Yale Department of Psychiatry in collaboration with the Clinical Neurosciences Division of the National Center for PTSD and the Yale Child Study Center would provide the environment for this training grant. The fellowship would last for two years with the option to continue for a third year. Each year, two new fellows would be selected for the program. Fellows will work closely with a Program Mentor and a separate Research Mentor. These mentors will oversee all of the fellow's research and training activities. The fellowship includes a core curriculum where trainees will develop skills related to research design and methodology, statistics, ethical conduct of research, psychological and behavioral assessment and the fundamentals of trauma-relevant neuroscience. Additionally, fellows will take elective courses related to their particular research area of interest. Trainees will begin their hands-on research activity by joining an ongoing project being conducted by their Research Mentor. Then, with the help of their Research Mentor, they will design and conduct their own trauma-related research project. The Department of Psychiatry, the Clinical Neuroscience Division of the National Center for PTSD, and the Yale Child Study Center all have outstanding records of training nationally prominent researchers in the basic and clinical neurosciences. The current application seeks to contribute toward the research objectives of NIMH by training postdoctoral fellows in neuroscience research related to disorders of extreme stress.