Research Training-Clinical Neurosciences-Stress Disorders

描述（由申请人提供）：本培训计划的主要目的是增加受过充分训练的研究人员的数量，这些研究人员从事与极端压力和创伤相关疾病（如创伤后应激障碍）相关的神经科学研究。在过去的十年中，在理解应激的生理、生物化学、神经回路、药理学和行为表现方面取得了卓越的临床前进展。这些进步现在已经可以测试关于人类压力相关疾病的病理生理学和治疗的合理假设。然而，目前很少有基础和临床神经科学家致力于将这些临床前研究结果转化为与压力相关的人类神经生物学研究。为了解决这一迫切需求，我们提议为博士后（高级精神病学住院医师、精神科医生和已完成创伤相关研究学科博士学位的博士，如神经科学、神经生物学、药理学和心理学）提供培训资助，他们寻求在极端压力和创伤相关疾病的神经生物学方面获得深入的研究培训。耶鲁精神病学系与国家创伤后应激障碍中心临床神经科学部和耶鲁儿童研究中心合作，将为这项培训拨款提供环境。该奖学金将持续两年，并可选择继续进行第三年。每年，该项目将选出两名新研究员。研究员将与项目导师和单独的研究导师密切合作。这些导师将监督该研究员的所有研究和培训活动。

DESCRIPTION (provided by applicant): The primary purpose of this training program is to increase the number of fully trained investigators who conduct neuroscience research related to extreme stress and trauma-related disorders, such as posttraumatic stress disorder. Over the past decade exceptional pre-clinical advances have been made in understanding the physiology, biochemistry, neural circuitry, pharmacology and behavioral manifestations of stress. These advances have now made it possible to test rational hypotheses regarding the pathophysiology and treatment of stress-related disorders in humans. However, currently there are relatively few basic and clinical neuroscientists who devote their career to translating these pre-clinical findings into relevant stress-related human neurobiological research. To address this pressing need, we propose a training grant for postdoctoral fellows (advanced psychiatry residents, psychiatrists, and PhDs who have completed their doctorate in disciplines relevant to trauma-related research such as neuroscience, neurobiology, pharmacology and psychology) who seek to gain in-depth research training in the neurobiology of extreme stress and trauma-related disorders. The Yale Department of Psychiatry in collaboration with the Clinical Neurosciences Division of the National Center for PTSD and the Yale Child Study Center would provide the environment for this training grant. The fellowship would last for two years with the option to continue for a third year. Each year, two new fellows would be selected for the program. Fellows will work closely with a Program Mentor and a separate Research Mentor. These mentors will oversee all of the fellow's research and training activities. The fellowship includes a core curriculum where trainees will develop skills related to research design and methodology, statistics, ethical conduct of research, psychological and behavioral assessment and the fundamentals of trauma-relevant neuroscience. Additionally, fellows will take elective courses related to their particular research area of interest. Trainees will begin their hands-on research activity by joining an ongoing project being conducted by their Research Mentor. Then, with the help of their Research Mentor, they will design and conduct their own trauma-related research project. The Department of Psychiatry, the Clinical Neuroscience Division of the National Center for PTSD, and the Yale Child Study Center all have outstanding records of training nationally prominent researchers in the basic and clinical neurosciences. The current application seeks to contribute toward the research objectives of NIMH by training postdoctoral fellows in neuroscience research related to disorders of extreme stress.