Alcohol Research Training in Neurosciences

描述(由申请者提供)：这是新墨西哥大学神经科学酒精培训项目(UNM-ARTN)的竞争性续签申请。该计划目前将结束第4年的支持。它对我们学院的研究生教育产生了非常积极的影响，并提高了校园内酒精研究的知名度。该计划提供多学科培训，包括分子生物学、生化、电生理、成像和行为技术。UNM-ARTN计划的重点是提供酒精神经科学研究方面的培训。我们小组在胎儿酒精谱系障碍研究的三个领域具有优势：1.涉及酒精神经畸形发生的基本机制；2.产前酒精暴露的生物标记物；以及3.改善FASD相关认知缺陷的治疗干预。此外，我们正在研究乙醇对不同脑区成熟神经元回路的短期和长期影响。神经科学系的七名教员(Allan、Caldwell、Cunning ham、Perrone-Bizzozero、Savage、Valenzuela、赵)和一名心理系(汉密尔顿)将作为核心教员直接参与该项目。核心教员的八名成员之间进行了广泛的互动。这一点从他们联合出版出版物、共同指导受训人员和合作赠款申请的记录中可见一斑。这些人将培训健康科学中心生物医学研究生项目的学生和心理学系认知、大脑和行为项目的学生。该计划每年将资助4名学生。除了这些项目的课程要求外，博士前实习生还将被要求完成特定的课程(酒精中毒的神经生物学；发育神经毒理学；基于问题的生物伦理学，科学写作)，并参加酒精研究期刊俱乐部。他们还将被要求提交博士前NRSA申请。该计划将由Valenzuela博士(主任)和Perrone-Bizzoero博士(联席主任)监督，执行委员会由培训人员组成，外部咨询委员会。我们将继续努力招募代表人数不足的少数族裔加入该计划。我们的目标是为高质量的研究生提供培训，为他们未来在酒精研究相关领域的成功职业生涯做好准备。这是对一个项目的竞争性续签申请，该项目将支持研究生在酒精神经科学研究方面的职业培训。酒精是一个主要的公共卫生问题；它是美国大量疾病、伤害和死亡的罪魁祸首。

DESCRIPTION (provided by applicant): This is a competitive renewal application for an Alcohol Training Program in Neurosciences at the University of New Mexico (UNM-ARTN). This program is currently ending Year 4 of support. It has had a tremendously positive impact on graduate education at our institution and has increased visibility of alcohol research across campus. The program provides multidisciplinary training that includes molecular biological, biochemical, electrophysiological, imaging and behavioral techniques. The focus of the UNM-ARTN program is to provide training in alcohol neuroscience research. Our group has strengths in three areas of fetal alcohol spectrum disorder research: 1. Basic mechanisms involved in ethanol neuroteratogenesis; 2. Biomarkers of prenatal alcohol exposure; and 3. Therapeutic interventions to ameliorate FASD-related cognitive deficits. In addition, we are investigating the short- and long-term effects of ethanol on mature neuronal circuits in different brain regions. Seven faculty members of the Department of Neurosciences (Allan, Caldwell, Cunninham, Perrone-Bizzozero, Savage, Valenzuela, Zhao) and one member of the Department of Psychology (Hamilton) will be directly involved in the program as core faculty. There have been extensive interactions among the eight members of the core faculty. This is evident by their record of joint publications, co-mentoring of trainees and collaborative grant applications. These individuals will train students from the Biomedical Sciences Graduate Program of the Health Sciences Center and students from the Cognition, Brain and Behavior Program of the Psychology Department. The program will support 4 students per year. In addition to the course requirements for each of these programs, predoctoral trainees will be required to complete specific courses (Neurobiology of Alcoholism; Developmental Neurotoxicology; Problem-based Bioethics, Scientific Writing), and participate in the Alcohol Research Journal Club. They will also be required to submit predoctoral NRSA applications. The program will be overseen by Drs. Valenzuela (Director) and Perrone-Bizzozero (Co-Director), an Executive Committee composed of members of the training faculty, and an external advisory committee. We will continue our efforts to recruit underrepresented minorities into the program. Our goal is to provide high quality graduate students with training that will prepare them for a successful future career in alcohol research relevance. This is a competitive renewal application for a program that will support training of graduate students for careers in alcohol neuroscience research. Alcohol is a major public health problem; it is responsible for a large number of illnesses, injuries and deaths in the United States.