A new coupling protocol for the synthesis of carbon-rich compounds.

有机化合物的制备，包括先进的有机材料，在很大程度上取决于选择性地在碳中心之间生成键的能力，最好是在温和(例如，相对较低的温度)条件下。温和的条件在化合物的制备中特别重要，这些化合物具有高度的不饱和度，并且除非有大的稳定基团保护，否则通常是高度活性的。为此，许多人一直在研究由许多不同的金属催化的广泛的C-C键形成反应，但通常是以钯和铜的组合为特征的。阿德莱德大学的布鲁斯教授发现了一种新的反应，可以从金试剂中形成C-C键。乍一看，考虑到黄金的成本，这似乎是一种倒退。然而，黄金化学也有一些特别的优势。例如，这些反应在室温下在乙醚或四氢呋喃中进行，而不是在已建立的铜和钯催化化学中使用的通常(可能更具活性的)胺溶剂中进行。此外，反应后，金以化学形式回收，可以直接收集和重新利用。我们现在希望能够更进一步地进行反应，并使用这种黄金化学在同一分子中实现多个连续的C-C键形成反应，然后将其从所需产品中分离出来并进行回收。金试剂也特别容易制备，而且可以在空气中操作。这在处理乙炔化合物时是一个很大的优势，因为相应的铜化合物容易爆炸分解。我们建议使用新的Bruce C-C偶联反应和易于制备和操作的乙炔的金衍生物来制备一系列高度不饱和的碳化合物。这些化合物有朝一日可能会被用作先进材料，但在这个阶段，我们真的会寻求将化学发展到一个可以被其他人使用的阶段。为了实现这一目标，我们想把布鲁斯教授带到英国，在那里他可以与刘特佐博士的团队合作，帮助发展这种化学。因此，这个项目寻求利用Bruce教授在他的耦合化学中提供的特殊经验组合和Low博士，Low博士不仅通过与Bruce教授的博士研究，而且通过他在加拿大与Arthur Carty的博士后工作以及他自己在达勒姆的交叉共轭碳框架工作，积累了一系列关于高碳含量材料的经验。我们还希望扩大可以从布鲁斯教授在英国的时间中受益的人数，为此，我们建议布鲁斯教授不仅在达勒姆，而且在全国其他大学化学系举办一系列讲座和研讨会。

The preparation of organic compounds, including advanced organic materials, depends heavily on the ability to generate bonds between carbon centres selectively, and preferably under mild (e.g. relatively low temperature) conditions. Mild conditions are especially important in the preparation of compounds which feature a high degree of unsaturatation and are often highly reactive unless protected by large stabilising groups. To this end many people have been working a wide range of C-C bond forming reactions catalysed by a number of different metals, but often which feature a combination of palladium and copper.Professor Bruce at the University of Adelaide has discovered a new reaction that allows the formation of C-C bonds from gold reagents. At first this might seem something of a backwards step, given the perceived expense of gold. However, there are some particular advantages to the gold chemistry. For example, the reactions proceed at room temperature in ether or thf rather than the usual (and potentially more reactive) amine solvents used in the established copper and palladium-catalysed chemistry. In addition, the gold is recovered after the reaction, in a chemical form that can be collected and re-used directly. We now hope to be able to take the reaction on one step further and use this gold chemistry to effect multiple sequential C-C bond forming reactions in the same molecule before separating it from the desired product and recycling. Gold reagents are also particularly easy to prepare and can handled in air. This is a great advantage when dealing with acetylenic compounds, as the corresponding copper compounds are prone to explosive decomposition. We propose to use the new Bruce C-C coupling reaction together with easily prepared and handled gold derivatives of acetylenes to prepare a range of highly unsaturated carbon compounds. These compounds may one day find use as advanced materials, but at this stage we would really seek to develop the chemistry to a stage where it can be used by others.To make this happen, we would like to bring Professor Bruce to the UK where he can work with Dr Low's group and help develop this chemistry. This project therefore seeks to use the particular combination of experience offered by Professor Bruce in his coupling chemistry and Dr Low, who has developed a range of experience with high-carbon content materials through not only his PhD studies with Professor Bruce, but also through his postdoctoral work in Canada with Arthur Carty and his own work with cross-conjugated carbon frameworks in Durham. We would also like to broaden the number of people who can benefit from Professor Bruce's time in the UK, and to do this we propose that Professor Bruce give a series of lectures and seminars not only in Durham, but also at other university chemistry departments around the country.