Neuronal Analysis of Cocaine Effects on Cognition
可卡因对认知影响的神经元分析
基本信息
- 批准号:7299966
- 负责人:
- 金额:$ 32.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-01 至 2012-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffectAnimal TestingAnimalsBehaviorBrainBrain regionCharacteristicsChronicClassificationCocaineCocaine AbuseCocaine DependenceCognitionCognitiveComplexComputer information processingConditionDecision MakingDorsalDrug AddictionDrug ControlsEffectivenessExposure toFire - disastersHealthcareHumanImpaired cognitionIndividualInjection of therapeutic agentJuiceLaboratoriesLaboratory StudyMedialMethodsModelingMonkeysNeuronsPathway interactionsPerformancePharmaceutical PreparationsPhysiologicalPopulationPositron-Emission TomographyPrefrontal CortexPrimatesProbabilityProceduresProcessPsyche structurePsychological reinforcementPurposeRateResearch PersonnelResearch Project GrantsRewardsSamplingShort-Term MemorySignal TransductionSleepSleep DeprivationSocietiesStressStructureSubstance AddictionTask PerformancesTechniquesTemporal LobeTestingTimeVentral StriatumWorkWorkplaceaddictionbasecognitive functioncopingdaydrug abuse preventionexecutive functionexpectationfunctional groupinsightnonhuman primatepressureprogramsreinforcerrelating to nervous systemstressor
项目摘要
DESCRIPTION (provided by applicant): The purpose of this research project is to assess the manner in which information processing in brain structures of nonhuman primates is re-organized by the introduction of and sustained exposure to cocaine as a reinforcer for complex cognitive tasks. It has long been implicitly assumed in analyses of human drug addiction that substances which are abused somehow take over normal reinforcement mechanisms in the brain, diverting such "reward pathways" to the control of drug seeking activities. Using a well-characterized short-term memory/executive function paradigm (multi-object delayed match to sample [DMS] task) studies will determine how cognitive processing is affected by acute and longterm exposure to cocaine as a reinforcer in this task. This primate model of cognitive function has been characterized in recent PET imaging and electrophysiological recording studies from this laboratory. On the basis of that work three important brain regions, medial temporal lobe (MTL), dorsal prefrontal cortex (DPFC) and the dorsal and ventral striatum (D/VStr), shown to be engaged during task performance, will be assessed for effects of cocaine on cognitive processing. Aim 1 will determine neuronal firing characteristics in these three brain regions associated with performance of the DMS task and will identify single neuron correlates of low vs. high cognitive load trials. Aim 2 will examine how these neural correlates change when the task is performed for cocaine injections delivered as the trial reinforcer in comparison to normal appetitive (juice) rewards. Aim 3 will extend the above analyses to animals that are repeatedly exposed to conditions in which cocaine and juice reinforcers are implemented in the same random manner during day-to-day testing for a period of six months in order to assess cumulative changes in DMS responding and associated neuronal correlates over a time period in which performance is sustained at criterion levels by both reinforcers. The final Aim 4 will assess the effects of stress on cocaine vs. juice reinforced DMS performance and associated neural correlates of cognitive load (Aim 1), induced by a method of sleep deprivation perfected for nonhuman primates in this laboratory.
Relevance: In a society that is evolving more and more toward increased stress and demand on its citizens the individual level of cocaine abuse is a major health care problem. Such behavior eventually results in inability of the addict to cope with the complex nuances of a complex technologically-based work place. Turning to drugs is a natural course of action for pressured, overworked and under employed personnel.How cocaine use advances to addiction in this context is directly related to effects on cognition, reasoning and decision making. Therefore understanding how cocaine modulates and gradually over time eliminates effective cognitive processing, as studied here, is of primary importance in the prevention of drug addiction.
描述(申请人提供):本研究项目的目的是评估非人类灵长类动物大脑结构中的信息处理方式是如何通过引入和持续暴露可卡因作为复杂认知任务的增强剂而重新组织的。长期以来,在对人类药物成瘾的分析中,人们一直隐含地假设,被滥用的物质以某种方式接管了大脑中正常的强化机制,将这种“奖励途径”转移到控制药物寻找活动上。使用一个表征良好的短期记忆/执行功能范式(多对象延迟匹配采样[DMS]任务),研究将确定在这项任务中,急性和长期暴露于可卡因作为增强剂对认知处理有何影响。这个灵长类动物的认知功能模型已经在本实验室最近的PET成像和电生理记录研究中得到了表征。在这项工作的基础上,将评估可卡因对认知加工的影响,这三个重要的大脑区域是内侧颞叶(MTL)、背侧前额叶(DPFC)和背侧和腹侧纹状体(D/VSTR),这些区域被证明在任务执行过程中参与。目标1将确定与DMS任务表现相关的这三个脑区的神经元放电特征,并将确定认知负荷低和高的试验中单个神经元的相关性。目标2将研究在注射可卡因作为试验增强剂时,与正常的食欲(果汁)奖励相比,这些神经关联是如何变化的。目标3将把上述分析扩展到在日常测试中以相同随机方式实施可卡因和果汁增强剂的反复暴露的动物,为期6个月,以评估在这两种增强剂将表现维持在标准水平的一段时间内DMS反应和相关神经元关联的累积变化。最终目标4将评估压力对可卡因和果汁增强的DMS表现的影响以及认知负荷的相关神经关联(目标1),这是由本实验室为非人类灵长类动物完善的睡眠剥夺方法诱导的。
相关性:在一个对公民的压力和需求越来越大的社会中,个人水平的可卡因滥用是一个主要的医疗保健问题。这种行为最终会导致上瘾者无法应对复杂的技术工作场所的复杂细微差别。对于压力大、工作过度和就业不足的人来说,求助于毒品是一种自然的行为过程。在这种情况下,可卡因的使用如何发展为成瘾,直接关系到对认知、推理和决策的影响。因此,了解可卡因是如何随着时间的推移调节并逐渐消除有效的认知处理的,就像这里研究的那样,对预防药物成瘾至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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专利数量(0)
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{{ truncateString('SAMUEL A. DEADWYLER', 18)}}的其他基金
Modulation of Radiation-induced Brain Injury in the Nonhuman Primate
非人类灵长类动物辐射引起的脑损伤的调节
- 批准号:
8824880 - 财政年份:2012
- 资助金额:
$ 32.32万 - 项目类别:
Modulation of Radiation-induced Brain Injury in the Nonhuman Primate
非人类灵长类动物辐射引起的脑损伤的调节
- 批准号:
8293574 - 财政年份:2012
- 资助金额:
$ 32.32万 - 项目类别:
Modulation of Radiation-induced Brain Injury in the Nonhuman Primate
非人类灵长类动物辐射引起的脑损伤的调节
- 批准号:
8461136 - 财政年份:2012
- 资助金额:
$ 32.32万 - 项目类别:
Neuroimaging Correlates of Cocaine Reinforcement for Cognitive Performance
可卡因强化认知表现的神经影像学相关性
- 批准号:
8580552 - 财政年份:2009
- 资助金额:
$ 32.32万 - 项目类别:
Neuroimaging Correlates of Cocaine Reinforcement for Cognitive Performance
可卡因强化认知表现的神经影像学相关性
- 批准号:
8411990 - 财政年份:2009
- 资助金额:
$ 32.32万 - 项目类别:
Neuroimaging Correlates of Cocaine Reinforcement for Cognitive Performance
可卡因强化认知表现的神经影像学相关性
- 批准号:
8214610 - 财政年份:2009
- 资助金额:
$ 32.32万 - 项目类别:
Neuroimaging Correlates of Cocaine Reinforcement for Cognitive Performance
可卡因强化认知表现的神经影像学相关性
- 批准号:
8012847 - 财政年份:2009
- 资助金额:
$ 32.32万 - 项目类别:
Neuronal Analysis of Cocaine Effects on Cognition
可卡因对认知影响的神经元分析
- 批准号:
7489960 - 财政年份:2007
- 资助金额:
$ 32.32万 - 项目类别:
Neuronal Analysis of Cocaine Effects on Cognition
可卡因对认知影响的神经元分析
- 批准号:
7880787 - 财政年份:2007
- 资助金额:
$ 32.32万 - 项目类别:
Neuronal Analysis of Cocaine Effects on Cognition
可卡因对认知影响的神经元分析
- 批准号:
8117259 - 财政年份:2007
- 资助金额:
$ 32.32万 - 项目类别:
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