Pediatric Oncology In Vivo Testing Program Coordinating Center
儿科肿瘤体内测试项目协调中心
基本信息
- 批准号:10300314
- 负责人:
- 金额:$ 84.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-25 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAntineoplastic AgentsBioinformaticsBiological ModelsCancer ModelCancer PatientChildChildhoodClinicalClinical TrialsCollaborationsCommunicationCommunitiesComplementDataData AnalysesData SecurityDatabase Management SystemsDatabasesDecision MakingDevelopmentEngineeringEnsureFDA approvedFoundationsGenerationsGenomicsGoalsInternationalLaboratoriesLeadershipLogisticsMalignant Childhood NeoplasmMalignant NeoplasmsMethodsMolecular TargetNew AgentsOnline SystemsPediatric OncologyPerformancePharmacologic SubstancePharmacologyPreclinical TestingProcessProgram EvaluationPropertyProtocols documentationPublicationsRecording of previous eventsResearchResearch PersonnelResource DevelopmentResource InformaticsResourcesSecureSiteStandardizationStatutes and LawsSystemSystems AnalysisTestingThe Jackson LaboratoryTherapeutic AgentsTimeVisionbasecancer genomicscancer therapycloud basedcohesiondata integritydata managementdata portalefficacy evaluationexperiencegenomics cloudhuman cancer mouse modelimproved outcomein vivoin vivo Modelin vivo evaluationmembermetadata standardsmodel developmentnew therapeutic targetnovel therapeuticspatient derived xenograft modelpediatric patientsprecision medicinepreclinical studyprogramspublic-private partnershipsoftware systemssuccesstargeted cancer therapytargeted treatmenttechnical reportuser-friendlyweb page
项目摘要
PROJECT SUMMARY
The overarching goal of NCI's Pediatric In Vivo Testing Program (Ped-In Vivo-TP) is to improve outcomes of
pediatric cancer patients and to satisfy the requirements of the Research to Accelerate Cures and Equity
(RACE) for Children Act to assess the efficacy of targeted anti-cancer agents developed for adults in pediatric
contexts. To coordinate the activities of the new Ped-In Vivo-TP initiative, we have assembled a team of
investigators from The Jackson Laboratory (JAX) and Seven Bridges Genomics (SB) with unique combined
expertise and experience with in vivo cancer models, scalable cloud-based data management and analysis
systems, informatics resource development, and multi-site project coordination. Combining the complementary
strengths of JAX and SB provides the ideal foundation for a coordinating center to maximize the short- and
long-term impacts of the Pediatric In Vivo Testing Program for advancing the application of precision medicine
in pediatric oncology. We will manage a comprehensive and cohesive testing program to advance precision
medicine in pediatric oncology through effective public-private partnerships among pharmaceutical companies,
regulatory agencies, funders, and research organizations. We will achieve this goal through the following aims:
Aim 1: Establish and maintain the Pediatric In Vivo Testing Coordinating Center (PIVOT CC) to provide
administrative and logistical support for diverse stakeholders in the Pediatric in Vivo Testing Program
consortium. We will draw on our team's combined decades of experience with multi-site program
management, cancer model development, standardized testing of in vivo cancer models, data management
and analysis, and informatics resource development to ensure timely decision making, conformance to
standard protocols, resource tracking, and effective communications within the Ped-In Vivo-TP. Aim 2:
Provide data management, statistical, and bioinformatics support to ensure data security and integrity.
We will leverage existing protocols and software systems at JAX and SB to identify relevant in vivo cancer
models and to collect, analyze, and securely manage data generated from testing centers within the
consortium. We will perform statistical and bioinformatic analyses on consortium data to reliably inform the
evaluation of the efficacy of novel therapeutic agents in a pediatric oncology setting. We will develop a public-
facing data portal for sharing of data and methods with the broader scientific community. Aim 3: Provide
scientific coordination to maintain an efficient and effective preclinical testing pipeline. We will draw
from the extensive experience of our team with in vivo pharmacology and coordination of similar consortia to
manage and coordinate the testing of agents by the Ped-In Vivo-TP centers at all stages of the process, from
the identification of relevant in vivo models to the generation of final technical reports and publication of results.
We will develop, record, and track performance metrics for the consortium to inform the evaluation of the
program's success and impact.
项目摘要
NCI的儿科体内测试计划(Ped-In Vivo-TP)的总体目标是改善
儿童癌症患者,并满足研究的要求,以加速治愈和公平
(RACE)儿童法案,以评估针对成人开发的儿童靶向抗癌药物的疗效
contexts.为了协调新的Ped-In Vivo-TP计划的活动,我们组建了一个团队,
来自杰克逊实验室(JAX)和七桥基因组公司(SB)的研究人员,
在体内癌症模型、可扩展的云数据管理和分析方面的专业知识和经验
信息系统、信息资源开发和多站点项目协调。结合互补性
JAX和SB的优势为协调中心提供了理想的基础,
儿科体内测试计划对推进精准医学应用的长期影响
儿科肿瘤学我们将管理一个全面和有凝聚力的测试计划,以提高精度
通过制药公司之间有效的公私伙伴关系,
监管机构、资助者和研究机构。我们将通过以下目标实现这一目标:
目标1:建立和维护儿科体内试验协调中心(PIVOT CC),
为儿科体内试验项目的不同利益相关者提供行政和后勤支持
财团我们将利用我们团队数十年的多站点项目经验
管理、癌症模型开发、体内癌症模型的标准化测试、数据管理
信息资源开发,以确保及时决策,
标准协议、资源跟踪和Ped-In Vivo-TP内的有效通信。目标二:
提供数据管理、统计和生物信息学支持,以确保数据的安全性和完整性。
我们将利用JAX和SB现有的协议和软件系统来识别相关的体内癌症
模型,并收集、分析和安全管理内部测试中心生成的数据
财团我们将对财团数据进行统计和生物信息学分析,以可靠地告知
评价新型治疗药物在儿科肿瘤学环境中的疗效。我们将建立一个公共-
面向数据门户,与更广泛的科学界分享数据和方法。目标3:提供
科学协调,保持高效的临床前试验管道。我们将抽取
从我们团队在体内药理学方面的丰富经验和类似联盟的协调,
管理和协调Ped-In Vivo-TP中心在过程的所有阶段对试剂的测试,从
识别相关的体内模型,以生成最终技术报告并发表结果。
我们将为联合体制定、记录和跟踪绩效指标,以告知对
计划的成功和影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CAROL J BULT其他文献
CAROL J BULT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CAROL J BULT', 18)}}的其他基金
JAX Diversity Action Plan (DAP) Post-Baccalaureate Program in Genomics (gDAP)
JAX 多样性行动计划 (DAP) 基因组学学士后计划 (gDAP)
- 批准号:
10555588 - 财政年份:2023
- 资助金额:
$ 84.72万 - 项目类别:
Pediatric Oncology In Vivo Testing Program Coordinating Center
儿科肿瘤体内测试项目协调中心
- 批准号:
10700004 - 财政年份:2021
- 资助金额:
$ 84.72万 - 项目类别:
Pediatric Oncology In Vivo Testing Program Coordinating Center
儿科肿瘤体内测试项目协调中心
- 批准号:
10474488 - 财政年份:2021
- 资助金额:
$ 84.72万 - 项目类别:
Aligning the Alliance of Genome Resources with FAIR and TRUST principles
使基因组资源联盟符合公平和信任原则
- 批准号:
10407901 - 财政年份:2019
- 资助金额:
$ 84.72万 - 项目类别:
Alliance Central: A platform for sustainable development of next generation genome knowledgebases
Alliance Central:下一代基因组知识库可持续发展的平台
- 批准号:
10020426 - 财政年份:2019
- 资助金额:
$ 84.72万 - 项目类别:
Alliance Central: A platform for sustainable development of next generation genome knowledgebases
Alliance Central:下一代基因组知识库可持续发展的平台
- 批准号:
10470142 - 财政年份:2019
- 资助金额:
$ 84.72万 - 项目类别:
Alliance Central: A platform for sustainable development of next generation genome knowledgebases
Alliance Central:下一代基因组知识库可持续发展的平台
- 批准号:
10683183 - 财政年份:2019
- 资助金额:
$ 84.72万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 84.72万 - 项目类别:
Research Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 84.72万 - 项目类别:
Standard Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 84.72万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 84.72万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 84.72万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 84.72万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 84.72万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 84.72万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 84.72万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 84.72万 - 项目类别:
Grant-in-Aid for Scientific Research (C)