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Prescription Opioids Among Street Drug Users: Medical Use, Misuse & Diversion

街头吸毒者中的处方阿片类药物：医疗用途、滥用

基本信息

批准号：
7372854
负责人：
WILLIAM R DAVIS
金额：
$ 33.98万
依托单位：
NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-01 至 2011-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7372854
关键词：
Accent Aging Appendix Awareness Categories Characteristics Chronic Classification Cocaine Cocaine Users Complement Complex Consumption Cross-Sectional Studies Data Drug Prescriptions Drug abuse Drug usage Drug user Ethnography Euphoria Europe Family Folklore Frequencies Government Heroin Heroin Users Illicit Drugs Ingestion Injection of therapeutic agent Interview Investigation Legal Link Literature Marijuana Marketing Medical Methadone Motivation New York City Numbers Opiate Addiction Opioid Oral Oxycodone Pain Pain management Pathway Analysis Patient Self-Report Patients Pattern Persons Pharmaceutical Preparations Pharmacists Pharmacologic Substance Pharmacy facility Physicians Pilot Projects Policies Population Powder dose form Prisons Process Purpose Recording of previous events Relative (related person)Reporting Research Risk Route Sales Schedule Social Network Source Street Drugs Surveys Target Populations Time Tranquilizing Agents Typology United States Update Variant Vicodin Withdrawal Youth addiction aged base convict drug market follow-up neglect offender pill prescription document prescription drug abuse prescription procedure prevent success theories young adult

项目摘要

DESCRIPTION (provided by applicant): Historically, New York City has had the largest number of heroin users in the U.S. (approximately 250,000). There is a need for a much clearer scientific understanding of prescription opioid (PO) medical use, misuse, and diversion among street drug users. The number of opioids available via prescription has increased, as have reports of their misuse. Street drug users are at high risk for misusing and illegally diverting POs, though this population may also use POs for appropriate medical reasons. There has been no broad-based longitudinal research with this significant population of drug users to determine the extent of PO use, misuse and diversion over time. An updated pilot study of over 700 NYC street drug users through 2006 found that nearly 90% used POs in their lifetimes and 60% used POs in the past month. OxyContin, Vicodin, and street methadone were the most often used, misused, and sold/diverted; the study found considerable variation in reasons for use, modes of use, and sources of POs. The proposed research aims to clarify the various motivations for PO use (e.g. pain relief, withdrawal avoidance, euphoria), routes of ingestion (e.g. oral as indicated, sniff/snort, injection), sources of supply (e.g. physicians/pharmacists, street dealers, family), and diversion/resale (e.g. use by someone else, resold, heroin substitute). The study will also document the impact of various regulatory policies to prevent misuse and diversion of POs. Social network theory provides the conceptual framework; this study will include a basic network analysis, comparing heroin and cocaine users'/sellers' networks with those predominantly using POs. Ethnographic data will complement the quantitative reports of resale activity. AIM A (Medical Use and Non-medical Misuse): Document and analyze patterns of PO consumption among street drug users in NYC. AIM B: Analyze the routes of diversion and markets for POs among street drug users in NYC. 500 street drug users will be interviewed regarding their use, misuse, and diversion of POs and followed-up after 6 months. 100 street drug users who report systematic diversion of POs will be interviewed in detail regarding episodes of diversion. Statistical analyses will document associations among other drug use, medical use of POs, and various forms of PO misuse. The research will provide systematic, longitudinal evidence about the extent of medical use, misuse, and diversion of POs within this population to help inform drug abuse control efforts.

描述（由申请人提供）：历史上，纽约市是美国吸食海洛因人数最多的城市（约 250,000 人）。需要对处方阿片类药物 (PO) 的医疗使用、滥用和街头吸毒者的转移有更清晰的科学认识。通过处方获得的阿片类药物数量有所增加，滥用阿片类药物的报道也有所增加。街头吸毒者滥用和非法转移 PO 的风险很高，尽管该人群也可能出于适当的医疗原因使用 PO。目前还没有对这一重要吸毒人群进行基础广泛的纵向研究，以确定随着时间的推移 PO 使用、滥用和转移的程度。一项针对 2006 年超过 700 名纽约市街头吸毒者的最新试点研究发现，近 90% 的人一生中使用过 PO，60% 的人在过去一个月使用过 PO。奥施康定、维柯丁和街头美沙酮是最常使用、滥用和出售/转移的药物；研究发现，PO 的使用原因、使用方式和来源存在很大差异。拟议的研究旨在阐明 PO 使用的各种动机（例如缓解疼痛、避免戒断、欣快感）、摄入途径（例如口服、嗅吸、注射）、供应来源（例如医生/药剂师、街头小贩、家庭）和转移/转售（例如其他人使用、转售、海洛因替代品）。该研究还将记录各种监管政策对防止 PO 滥用和转移的影响。社会网络理论提供了概念框架；这项研究将包括基本网络分析，将海洛因和可卡因使用者/销售者网络与主要使用 PO 的网络进行比较。人种学数据将补充转售活动的定量报告。 AIM A（医疗用途和非医疗滥用）：记录并分析纽约市街头吸毒者的 PO 消费模式。目标 B：分析纽约市街头吸毒者的吸毒者转移路线和市场。 500 名街头吸毒者将接受采访，了解他们使用、滥用和转移 PO 的情况，并在 6 个月后进行随访。 100 名报告系统性转移 PO 的街头吸毒者将接受有关转移事件的详细访谈。统计分析将记录其他药物使用、PO 的医疗使用以及各种形式的 PO 滥用之间的关联。该研究将提供有关该人群中 PO 的医疗使用、滥用和转移程度的系统、纵向证据，以帮助为药物滥用控制工作提供信息。