Computer-based brief intervention for perinatal drug, alcohol, and tobacco abuse

针对围产期药物、酒精和烟草滥用的基于计算机的简短干预

• 批准号: 7406870
• 负责人: STEVEN J. ONDERSMA
• 金额: $ 29.71万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-10 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7406870
• 关键词: Abstinence; Address; Affect; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Anger; Arts; Asthma; Attention; Behavior Therapy; Blinded; Breath Tests; Brestan; Caring; Child; Clinical Trials; Cocaine; Cognitive Therapy; Collaborations; Communities; Computer software; Computers; Condition; Control Groups; Data; Data Analyses; Discipline of obstetrics; Drug abuse; Drug usage; Effectiveness of Interventions; Financial cost; HIV; Hair; Health; Home environment; Hospitals; Illicit Drugs; Individual; Infant; Intervention; Language; Lead; Measures; Mediating; Mediator of activation protein; Medical; Methods; Mothers; Motivation; Opiates; Outcome; Participant; Patient Self-Report; Perinatal; Persons; Pharmaceutical Preparations; Population; Postpartum Women; Primary Health Care; Provider; Psychopathology; Public Health; Randomized; Range; Rate; Readiness; Recruitment Activity; Reporting; Research; Research Personnel; Risk; Risk Behaviors; Risk-Taking; Sampling; Screening procedure; Smoke; Smoking; Staging; Substance Use Disorder; Substance abuse problem; System; Testing; Time; Tobacco; Tobacco use; Training; Treatment Cost; Urine; Violence; Woman; base; cost; early /brief intervention /therapy; experience; facsimile; follow-up; interest; intimate partner violence; motivational enhancement therapy; motivational intervention; neglect; prenatal smoking; programs; size; social; software development; stem; theories; therapy development; tobacco abuse; treatment program; ward

DESCRIPTION (provided by applicant): The health-related, social, and financial costs of drug abuse are well-known; these costs are only multiplied when perinatal drug use and associated risks (such as HIV) also place an infant at risk, both prenatally and postnatally. A range of relevant treatment programs exist, but such programs are not able to either reach all women who are in need of treatment, or to engage many of those they do identify and intend to treat. Even brief motivational interventions in primary care - despite tremendous promise - are limited by the amount of time, training, expertise, and interest they require from primary care providers. In contrast, computer-based brief interventions could allow access to high proportions of women using drugs during the perinatal period. Computers could also do so at very low cost, and with perfect replication in the community. A computer-based brief motivational intervention developed under a Stage I R21 has shown early promise: at 3-month follow-up in a preliminary clinical trial, postpartum women randomly assigned to a 20-minute computer-based brief intervention were 3 times less likely to be using either cocaine, other stimulants, or opiates. In this Stage II application, this research will be expanded in two ways. First, the intervention will be modified based on data from the preliminary clinical trial, and tested in a larger sample of drug-using postpartum women. Second, the intervention will be extended to also address problem alcohol use and prenatal smoking. Specifically, this research will: (a) revise and upgrade software based on data from the initial clinical trial; (b) recruit 500 post-partum women (200 screening positive for illicit drug use, 150 screening positive for problem alcohol abuse, and 150 screening positive for smoking) from an urban obstetric hospital; and (c) randomly assign women into intervention and control conditions, with blinded follow-up assessments at 3- and 6-months. In addition to testing the effect of the intervention on substance use outcomes (as measured by self-report and toxicological analysis) and related outcomes (such as HIV risk), data analyses will also examine theory-driven mediators and moderators of any observed association between the brief intervention and outcomes. This research could enhance public health by making available an effective, practical, low-cost, and high-reach intervention for all forms of perinatal substance abuse.

描述（由申请人提供）：药物滥用造成的健康、社会和财务成本是众所周知的；只有当围产期吸毒和相关风险（例如艾滋病毒）也使婴儿在产前和产后面临风险时，这些成本才会成倍增加。存在一系列相关的治疗计划，但这些计划既无法惠及所有需要治疗的女性，也无法吸引许多她们确定并打算治疗的女性。即使在初级保健中进行短暂的激励干预——尽管前景广阔——也会受到初级保健提供者所需的时间、培训、专业知识和兴趣的限制。相比之下，基于计算机的简短干预措施可以让高比例的围产期吸毒妇女获得帮助。计算机也可以以非常低的成本做到这一点，并在社区中完美复制。根据第一阶段 R21 开发的基于计算机的简短动机干预措施已显示出早期前景：在初步临床试验的 3 个月随访中，随机分配接受 20 分钟基于计算机的简短干预的产后妇女使用可卡因、其他兴奋剂或阿片类药物的可能性降低了 3 倍。在第二阶段的应用中，这项研究将在两个方面进行扩展。首先，干预措施将根据初步临床试验的数据进行修改，并在更大的吸毒产后妇女样本中进行测试。其次，干预措施将扩大到解决饮酒和产前吸烟问题。具体来说，本研究将：（a）根据初始临床试验的数据修改和升级软件； (b) 从城市产科医院招募500名产后妇女（200名非法药物使用筛查呈阳性、150名酗酒筛查呈阳性、150名吸烟筛查呈阳性）； (c) 将妇女随机分配到干预条件和对照条件下，并在 3 个月和 6 个月时进行盲法随访评估。除了测试干预措施对物质使用结果（通过自我报告和毒理学分析衡量）和相关结果（例如艾滋病毒风险）的影响外，数据分析还将检查短期干预与结果之间任何观察到的关联的理论驱动的中介因素和调节因素。这项研究可以通过为所有形式的围产期药物滥用提供有效、实用、低成本和高影响力的干预措施来增强公众健康。