Molecular Biology of Eukaryotic Viruses

真核病毒分子生物学

• 批准号: 7503073
• 负责人: Bert L Semler
• 金额: $ 10.05万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7503073
• 关键词: Molecular Biology; Virus

DESCRIPTION (provided by applicant): This proposal is a competing renewal application for continuing support of a training program in the Molecular Biology of Eukaryotic Viruses, established at the University of California, Irvine (UCI) in 1988. The goal of this program is to train Ph.D. graduate students in the fundamental aspects of molecular virology as they relate to the regulation of gene expression, virus structure, virus-host interactions, and pathogenesis. During the past review period (9/02-8/07), eight predoctoral students were supported by this training program. An expansion of interdisciplinary research and training programs in the areas of structural biology/proteomics, virus-host interactions, and viruses requiring BSL-3 containment is proposed for the next five years. The number of faculty mentors for this program has been expanded to 15, representing four academic departments at UCI. Faculty members from these departments, along with those from other departments in the School of Biological Sciences and the School of Medicine, participate in the Graduate Program in Molecular Biology, Genetics, & Biochemistry (MBGB) at UCI, which oversees recruitment, admission, and initial training of predoctoral students. All of the NIH Virology Grant trainees belong to the Virology Track in the MBGB program. This track is comprised of faculty, students, postdoctoral fellows, and laboratory staff who have shared research interests in virology and related disciplines. The Virology training program includes elective courses in viral gene expression, molecular pathogenesis of viral infections, and immunopathogenic mechanisms of disease. The research programs of faculty participants include the study of viral genome replication, viral-specific transcription, RNA processing, viral translation and protein processing, assembly and transport of viral structural proteins, and the structures of virus particles. The virology faculty are also studying virus-host interactions that include alteration of host regulatory molecules, growth control, cell cycle regulation, the mechanisms of integration of viral genomes into host cell DNA, and the subversion of host functions for virus gene expression. The viruses/viral systems being studied include murine leukemia virus, a sheep retrovirus (JSRV), HIV, yeast Ty3, poliovirus, human rhinovirus, coxsackievirus, mouse hepatitis virus, SARS coronavirus, arenaviruses, herpes simplex virus, Epstein-Barr virus, human papillomavirus, vaccinia virus, and a number of RNA-containing plant viruses.

描述（由申请人提供）：本提案是一项竞争性续期申请，旨在继续支持1988年在加州大学欧文分校（UCI）建立的真核病毒分子生物学培训项目。该计划的目标是培养博士。研究生在分子病毒学的基本方面，因为他们涉及到基因表达，病毒结构，病毒宿主相互作用的调节，和发病机制。在过去的审查期间（9/02-8/07），八个博士生支持这个培训计划。在结构生物学/蛋白质组学，病毒-宿主相互作用和需要BSL-3遏制病毒领域的跨学科研究和培训计划的扩展，提出了在未来五年。该计划的教师导师人数已扩大到15人，代表UCI的四个学术部门。来自这些部门的教职员工，沿着来自生物科学学院和医学院其他部门的教职员工，参加UCI的分子生物学，遗传学和生物化学研究生课程（MBGB），该课程负责招聘，录取和博士前学生的初步培训。所有NIH病毒学资助的受训人员都属于MBGB计划中的病毒学轨道。这条赛道由教师，学生，博士后研究员和实验室工作人员组成，他们在病毒学和相关学科中有共同的研究兴趣。病毒学培训课程包括病毒基因表达，病毒感染的分子发病机制和疾病的免疫发病机制的选修课程。教师参与的研究项目包括病毒基因组复制，病毒特异性转录，RNA加工，病毒翻译和蛋白质加工，病毒结构蛋白的组装和运输以及病毒颗粒的结构的研究。病毒学系也在研究病毒与宿主的相互作用，包括宿主调节分子的改变、生长控制、细胞周期调节、病毒基因组整合到宿主细胞DNA中的机制，以及病毒基因表达的宿主功能的颠覆。正在研究的病毒/病毒系统包括鼠白血病病毒、绵羊逆转录病毒（JSRV）、HIV、酵母Ty 3、脊髓灰质炎病毒、人鼻病毒、柯萨奇病毒、小鼠肝炎病毒、SARS冠状病毒、沙粒病毒、单纯疱疹病毒、EB病毒、人乳头瘤病毒、牛痘病毒和许多含RNA的植物病毒。