HLA-G/H2-Bl is Critical for Regulating Inflammation in the Liver

炎症是导致肝纤维化、进展为肝硬变和肝细胞癌的关键因素。肝移植和肝切除后的肝再生也因炎症升高而显著受损。我们已经确定了一种有效的抗炎蛋白--人类白细胞抗原-G，它对调节肝脏术后炎症是至关重要的。我们将确定人类白细胞抗原-G是否可以逆转和/或阻断肝纤维化，并对人类白细胞抗原-G进行修饰以提高临床潜力。

The key factor to induction of liver fibrosis, progression to cirrhosis, and hepatocellular carcinoma is inflammation. Liver transplant and liver regeneration following liver resection are also dramatically impaired by elevation of inflammation. We have identified a potent anti-inflammatory protein, HLA-G, that is critical for regulating post-surgical inflammation in the liver. We will determine if HLA-G can reverse and/or block liver fibrosis and modify HLA-G for improved clinical potential.