Roles of the nuclear growth hormone receptor in cell proliferation and survival

核生长激素受体在细胞增殖和存活中的作用

• 批准号: nhmrc : 1025088
• 负责人: Dr Andrew Brooks
• 金额: $ 28.63万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/roles-nuclear-growth-proliferation-survival/110403
• 关键词: Roles; nuclear; growth; hormone; receptor

We have discovered that the cell surface receptor for growth hormone travels to the cell nucleus in dividing cells, including cancer cells. Given the role of growth hormone in promoting growth postnatally, we seek to uncover how the nuclear receptor promotes proliferation directly, and by gene splicing. We have identified strong candidates for its direct actions through proteomics, and a DNA binding site for the receptor. Here we will investigate its role in proliferation, gene splicing and DNA strand break repair after cell irradiation.

我们已经发现，生长激素的细胞表面受体在分裂细胞（包括癌细胞）中转移到细胞核。鉴于生长激素在促进出生后生长中的作用，我们试图揭示核受体如何直接促进增殖，并通过基因剪接。我们已经通过蛋白质组学确定了其直接作用的强有力的候选者，以及受体的DNA结合位点。在这里，我们将探讨它在细胞增殖，基因剪接和DNA链断裂修复后照射的作用。