HLA-G/H2-Bl is Critical for Regulating Inflammation in the Liver

HLA-G/H2-Bl 对于调节肝脏炎症至关重要

• 批准号: nhmrc : 1124026
• 负责人: Dr Andrew Brooks
• 金额: $ 33.68万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hla-gh2-bl-inflammation-liver/947263
• 关键词: HLA; H2; Bl; Critical; Regulating

The key factor to induction of liver fibrosis, progression to cirrhosis, and hepatocellular carcinoma is inflammation. Liver transplant and liver regeneration following liver resection are also dramatically impaired by elevation of inflammation. We have identified a potent anti-inflammatory protein, HLA-G, that is critical for regulating post-surgical inflammation in the liver. We will determine if HLA-G can reverse and/or block liver fibrosis and modify HLA-G for improved clinical potential.

炎症是导致肝纤维化、发展为肝硬化和肝癌的关键因素。肝移植和肝切除后的肝再生也会因炎症的升高而显著受损。我们已经确定了一种有效的抗炎蛋白HLA-G，它对调节肝脏手术后炎症至关重要。我们将确定HLA-G是否可以逆转和/或阻断肝纤维化并修饰HLA-G以提高临床潜力。