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Population genetic structure and bionomics of Anopheles lesteri in China

中国莱氏按蚊种群遗传结构及生物学特征

基本信息

批准号：
7227504
负责人：
YAJUN MA
金额：
$ 5.24万
依托单位：
SECOND MILITARY MEDICAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2008-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7227504
关键词：
Anopheles Genus Antimalarials Area Asia Bionomics Blood China Classification Communities Comprehension Condition County Culicidae Cytochromes Disease Outbreaks Ecology Enzyme-Linked Immunosorbent Assay Epidemic Exhibits Far East Figs - dietary Fostering Genes Genetic Genetic Structures Genotype Goals Habitats Human Incidence Individual Infection Japan Karyotype Knowledge Korea Link Malaria Methods Mitochondrial DNA Modeling Molecular Numbers Outcome Parasites Pharmaceutical Preparations Philippines Plasmodium Plasmodium vivax Population Population Biology Population Genetics Production Province Public Health Range Rate Research Siblings Source South Korea Staging Taxonomy Testing Time Vietnam World Health Organization cytochrome c oxidase design feeding geographic difference improved population genetic structure preference transmission process trend vector vector control

项目摘要

DESCRIPTION (provided by applicant): Project Summary: Malaria is an important public health problem in China. The World Health Organization estimated that the annual number of malaria cases in China was about 740,000 in 2003. Malaria outbreaks often occur in central China. The mosquito Anopheles lesteri is the primary malaria vector in China and Korea, and it is highly susceptible to both Plasmodium vivax and P. falciparum. Despite the importance of A. lesteri in malaria transmission, little is known about the population genetics and ecology of this malaria vector species. The scantiness of research on A. lesteri population has been partly due to difficulties with its taxonomy and inadequate means of identifying the species. In the past several years we have developed a molecular identification method to distinguish A. lesteri from sibling species, thus enabling us to study the ecology and genetics of this important malaria vector. Preliminary studies suggest that the morphological characters, bionomics (such as host preference and larval habitat), and chromosomal karyotype of A. lesteri differ among populations from different geographic localities. The proposed research aims to improve our understanding of the population genetic structure and bionomics of A. lesteri in China. The 2 specific aims are: 1) To determine the population genetic structure of A. lesteri, and 2) To examine geographic variation in A. lesteri bionomics, including host-feeding preference and larval habitat selection. A unique aspect of this project is that it links the population genetics of A. lesteri with its ecology. The anticipated outcomes of this project include a better understanding of the ecology and genetics of A. lesteri mosquitoes as well as the geographic variation of its bionomics. This information is particularly useful for the design of rational area-specific vector control methods.

项目内容：疟疾是中国一个重要的公共卫生问题。据世界卫生组织估计，2003年中国每年的疟疾病例约为74万例。中国中部经常发生疟疾疫情。雷氏按蚊是中国和韩国的主要疟疾传播媒介，对间日疟原虫和恶性疟原虫高度易感。尽管A. lesteri在疟疾传播中，人们对这种疟疾病媒物种的种群遗传学和生态学知之甚少。对A. lesteri种群的部分原因是其分类困难和识别物种的手段不足。在过去的几年里，我们已经发展了一种分子鉴定方法来区分A。因此，我们能够研究这种重要疟疾病媒的生态学和遗传学。初步研究表明，该虫的形态特征、生物学特性（如寄主选择性和幼虫生境）和染色体核型与其寄主的关系密切。不同地理位置的群体中的莱斯特氏菌有所不同。本研究旨在加深对该虫种群遗传结构和生物学特性的认识。中国的莱斯特。2个具体目的是：1）确定黑绒蒿种群的遗传结构; lesteri的地理变异; lesteri生物学，包括寄主取食偏好和幼虫栖息地选择。该项目的一个独特之处在于它将A.莱斯特里及其生态。该项目的预期成果包括更好地了解A.莱斯特蚊及其生物学特性的地理变异。这一信息对于设计合理的针对具体地区的病媒控制方法特别有用。