Washington University Center for Translational Neuroscience

华盛顿大学转化神经科学中心

• 批准号: 7291536
• 负责人: DAVID M. HOLTZMAN
• 金额: $ 167.32万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7291536
• 关键词: Washington; University; Center; Translational; Neuroscience

DESCRIPTION (provided by applicant): The overarching goal of this grant, entitled "Washington University Center for Translational Neuroscience- WUCTN" is to support centralized resources, facilities, and expertise shared by neuroscience investigators at Washington University in order to facilitate discovery of fundamental mechanisms of disorders of the nervous system and to translate this understanding into treatments and cures. Core A, Administration, will organize and facilitate interaction among the 6 other cores: Core B, Biospecimen and Clinical Data Acquisition; Core C, Molecular Analysis; Core D, Viral Vectors; Core E, Optical imaging; Core F, Functional Assessment; and Core G, Informatics. By pooling and organizing resources and expertise, the enormous breadth and collaborative spirit of the Washington University neuroscience community that spans virtually every department, can take advantage of economies of scale, confront challenges too large for individual investigators, and develop an infrastructure that will serve the user group of over 120 investigators. The WUCTN will capitalize on the development and resources of 3 new initiatives at Washington University: Biomed 21, the Hope Center for Neurological Disorders, and the Neurological Clinical Research Unit as well as utilize the support and expertise of the long established McDonnell Neuroscience Centers to assist in supporting the personnel and infrastructure being requested in this proposal. In addition, we will work together with several ongoing NIH funded centers at Washington University including the Alzheimer's Disease Research Center, the Conte Center for research on the neurobiology of schizophrenia, and the NINDS Center Core for Brain Imaging to add "extra value" to this proposal. The increasing complexity and cost of the technologies required to characterize biological phenomenon are often beyond the expertise and resources of an individual laboratory. This makes it very difficult to establish and validate key new discoveries in a cohesive, timely, and cost-efficient manner without access to facilities specializing in these enabling technologies. The proposed Core infrastructure, situated within the collaborative environment that exists between the basic neurosciences and the neurobiology of disease community at Washington University, will help catalyze a strong translational effort to convert basic discoveries into diagnostic and therapeutic advances. This will be manifested as: 1) greater efficiency in utilizing enabling technologies by individual investigators; 2) greater collaboration aimed at pre-clinical development of potential therapeutic strategies; and, 3) faster translation of initial discoveries into useful treatments for disorders of the nervous system. Relevance to public health: This Core grant will establish enabling technology resources and technical expertise to facilitate the transition of basic neuroscience discoveries relevant to neurologic and psychiatric diseases into novel diagnostic and therapeutic opportunities.

描述（由申请人提供）：该基金的总体目标是“华盛顿大学转化神经科学中心- WUCTN”，旨在支持华盛顿大学神经科学研究人员共享的集中资源、设施和专业知识，以促进发现神经系统疾病的基本机制，并将这种理解转化为治疗和治愈。 核心A，行政管理，将组织和促进其他6个核心之间的互动：核心B，生物标本和临床数据采集;核心C，分子分析;核心D，病毒载体;核心E，光学成像;核心F，功能评估;核心G，信息学。 通过汇集和组织资源和专业知识，华盛顿大学神经科学界的巨大广度和协作精神几乎跨越了每个部门，可以利用规模经济，面对个体研究者面临的挑战太大，并开发一个基础设施，将服务于超过120名研究者的用户组。 WUCTN将利用华盛顿大学3项新举措的发展和资源：Biomed 21、神经疾病希望中心和神经临床研究单位，并利用历史悠久的McDonnell神经科学中心的支持和专业知识，协助支持本提案中要求的人员和基础设施。 此外，我们将与华盛顿大学的几个正在进行的NIH资助的中心合作，包括阿尔茨海默病研究中心，康特精神分裂症神经生物学研究中心和NINDS脑成像中心核心，为这一提议增加“额外价值”。 描述生物现象所需技术的复杂性和成本不断增加，往往超出了单个实验室的专业知识和资源。 这使得如果没有专门从事这些使能技术的设施，就很难以一种连贯、及时和具有成本效益的方式建立和验证关键的新发现。 拟议中的核心基础设施位于华盛顿大学基础神经科学和疾病社区神经生物学之间的合作环境中，将有助于促进将基础发现转化为诊断和治疗进展的强大转化努力。 这将表现为：1）个体研究者更有效地利用使能技术; 2）旨在临床前开发潜在治疗策略的更大合作;以及3）更快地将初步发现转化为神经系统疾病的有用治疗方法。 与公共卫生的相关性：该核心赠款将建立使能技术资源和技术专长，以促进与神经和精神疾病相关的基础神经科学发现向新的诊断和治疗机会的过渡。