Washington University Chronic KidneyDisease National Resource Center
华盛顿大学慢性肾病国家资源中心
基本信息
- 批准号:10747719
- 负责人:
- 金额:$ 90.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdoptedAffectAreaBar CodesBenignBiological AssayCRISPR/Cas technologyCardiovascular systemCell Culture TechniquesCell NucleusCellsChronicChronic Kidney FailureCodeCommunicationCommunitiesConsultationsData AnalysesDevelopmentDiseaseDiverse WorkforceDoctor of MedicineDoctor of PhilosophyEducationEquipmentEvolutionFamilyFibrosisFunctional disorderFundingGenesGeneticGenetic TechniquesGenomic medicineGenus HippocampusGoalsIn VitroIncubatorsInjuryInjury to KidneyKidneyLeadLeadershipMetabolicMetabolismModelingMorbidity - disease rateMusPathogenicityPathologicPatientsPopulationPre-Clinical ModelProteinsProtocols documentationRNA SplicingRadioactiveResearchResearch PersonnelResolutionResource DevelopmentResource SharingResourcesScientific Advances and AccomplishmentsServicesStudentsTechniquesTechnologyTestingTimeTissuesTracerTrainingTubular formationUnderrepresented MinorityUnited States National Institutes of HealthUniversitiesValidationVariantWashingtonWorkbioinformatics pipelinebiomedical resourcecomputational pipelinescostgenetic testinggenetic varianthands on instructionimprovedin silicoin situ sequencingin vitro Assayin vivokidney biopsykidney metabolismmetabolomicsmortalitymultiple omicsnovel therapeutic interventionoxidationprogramsrecruitresponse to injurysingle cell technologystable isotopesummer studenttechnological innovationtooltranscriptomicsvariant of unknown significance
项目摘要
Project Summary/Abstract: Overall Component
The Washington University Chronic Kidney Disease National Resource Center is focused on the significant
problem of chronic kidney disease (CKD), which affects almost 15% of the US population and carries
significant morbidity and mortality. Several scientific advances have the promise to accelerate CKD research,
but many of these advances are not accessible to the kidney research community due to limited expertise
and/or the need for expensive equipment. Thus, this NRC will address the fundamental challenge of providing
better access to cutting-edge techniques in single cell omics, genetics, and metabolism to the kidney research
community to facilitate advances in CKD research. Dr. Ben Humphreys is the overall program director, and this
Center will consist of four Cores: an Administrative Core, two Biomedical Resource Cores, and a Resource
Development Core. The Administrative Core will oversee distribution of funds across the Cores, communicate
with the National O’Brien Consortium, manage the Summer Student Enrichment Program, and promote the
involvement of early stage investigators and a diverse workforce. The Variant Validation Core, one of the
Biomedical Resource Cores, investigates the pathogenicity of genetic variants of uncertain significance using
CRISPR/Cas9-gene editing, in silico approaches, and tailored in vitro assays. The Metabolism Core, the other
Biomedical Resource Core, provides consultation for users and access to a number of metabolic assays to
interrogate changes in kidney metabolism relevant to CKD. These assays include Seahorse bioflux analysis,
radioactive substrate oxidation assays of tissue ex vivo, untargeted metabolomics, and stable isotope tracer
studies. The Metabolism Core will also work with the O’Brien Consortium to provide validated protocols for
assays commonly performed (e.g. Seahorse assays on primary cells) and provide hands’ on training using
these protocols. The Single Cell Omics Research Evolution (SCORE) Core is the Resource Development
Core, which develops protocols and bioinformatics pipelines for cutting-edge techniques like split pool
barcoding for single nuclei multi-omics and high resolution in-situ sequencing-based spatially resolved
transcriptomics. All four Cores will work together and with the network of O’Brien National Resource Centers to
make scientific advancements more accessible to the kidney research community with particular emphasis on
junior investigators and development of a diverse biomedical workforce.
项目摘要/摘要:总体构成
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BENJAMIN D. HUMPHREYS其他文献
BENJAMIN D. HUMPHREYS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BENJAMIN D. HUMPHREYS', 18)}}的其他基金
Understanding Myofibroblast Progenitor Fate and Function in Renal Fibrosis
了解肾纤维化中肌成纤维细胞祖细胞的命运和功能
- 批准号:
9302747 - 财政年份:2015
- 资助金额:
$ 90.48万 - 项目类别:
Mechanisms of Successful vs. Failed Kidney Repair
肾脏修复成功与失败的机制
- 批准号:
10385841 - 财政年份:2015
- 资助金额:
$ 90.48万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 90.48万 - 项目类别:
Research Grant